Potential impact of severe hydronephrosis secondary to ureteropelvic junction obstruction on pediatric blood pressure

被引：0

作者：

Tian, Qingqing ^{[1
]}

Zhang, Chu ^{[1
]}

Zhao, Xiang ^{[1
]}

Yu, Kechi ^{[1
]}

Fang, Erhu ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Niu, Yonghua ^{[1
]}

Li, Ning ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat Surg, Wuhan, Peoples R China

来源：

JOURNAL OF PEDIATRIC UROLOGY | 2025年 / 21卷 / 01期

关键词：

Hydronephrosis; Ureteropelvic junction obstruction; Blood pressure; Children; Renin; Aldosterone; SALT-SENSITIVE HYPERTENSION;

D O I：

10.1016/j.jpurol.2024.10.014

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This study enrolled 114 children with severe hydronephrosis secondary to UPJO and 153 without nephritic or cardiovascular conditions between September 2021 and June 2023. As the control group aged, SBP and DBP increased, whereas ARC and AC decreased. Overall, hydronephrosis group had higher SBP, DBP, ARC, and AC than the controls group. These differences differed between the age groups. After pyeloplasty, the postoperative BP of hydronephrosis group approximated that of the control group. Postoperative ARC levels were higher than those in the control group but were much lower than the preoperative levels. AC did not decrease significantly after surgery. The change in DBP in children with hydronephrosis before and after pyeloplasty showed a positive correlation with the change in AC. renin-angiotensin-aldosterone system (RAAS) were examined. Results This study enrolled 114 children with severe hydronephrosis secondary to UPJO and 153 without nephritic or cardiovascular conditions between September 2021 and June 2023. As the control group aged, SBP and DBP increased, whereas ARC and AC decreased. Overall, hydronephrosis group had higher SBP, DBP, ARC, and AC than the controls group. These differences differed between the age groups. After pyeloplasty, the postoperative BP of hydronephrosis group approximated that of the control group. Postoperative ARC levels were higher than those in the control group but were much lower than the preoperative levels. AC did not decrease significantly after surgery. The change in DBP in children with hydronephrosis before and after pyeloplasty showed a positive correlation with the change in AC. Conclusions Pediatric patients with severe hydronephrosis, a condition secondary to UPJO, displayed elevated BP, ARC, and AC. Following pyeloplasty, these patients noted a reduction in BP. The correlation between elevated blood pressure and the RAAS necessitates further comprehensive investigation.

引用

页码：108 / 114

页数：7

共 50 条

[1] Ureteropelvic Junction Obstruction/ Hydronephrosis
Cai, Peter Y.
Lee, Richard S.
UROLOGIC CLINICS OF NORTH AMERICA, 2023, 50 (03) : 361 - 369
[2] Pediatric congenital hydronephrosis (ureteropelvic junction obstruction): Medical management guide
Kohno, Miyuki
Ogawa, Tetsushi
Kojima, Yoshiyuki
Sakoda, Akiko
Johnin, Kazuyoshi
Sugita, Yoshifumi
Nakane, Akihiro
Noguchi, Mitsuru
Moriya, Kimihiko
Hattori, Motoshi
Hayashi, Yutaro
Kubota, Masayuki
INTERNATIONAL JOURNAL OF UROLOGY, 2020, 27 (05) : 369 - 376
[3] Inferior Vena Cava Thrombus Secondary to Ureteropelvic Junction Obstruction with Severe Hydronephrosis
Yeaman, Clinton
Peruri, Adithya
Rodriguez-Carpio, Tania
Sharma, Aditya
Ramcharitar, Randy
Krupski, Tracey
Khaja, Minhaj
CURRENT MEDICAL IMAGING, 2022, 18 (03) : 353 - 356
[4] Intermittent hydronephrosis secondary to ureteropelvic junction obstruction: Clinical and imaging features
Tsai, JD
Huang, FY
Lin, CC
Tsai, TC
Lee, HC
Sheu, JC
Chang, PY
PEDIATRICS, 2006, 117 (01) : 139 - 146
[5] The Management of Ureteropelvic Junction Obstruction Presenting with Prenatal Hydronephrosis
Herndon, C. D. Anthony
Kitchens, David M.
THESCIENTIFICWORLDJOURNAL, 2009, 9 : 400 - 403
[6] Surgical outcomes of laparoscopic dismembered pyeloplasty in children with giant hydronephrosis secondary to ureteropelvic junction obstruction
Nerli, R. B.
Reddy, M. N.
Hiremath, M. B.
Shishir, D.
Patil, S. M.
Guntaka, A.
JOURNAL OF PEDIATRIC UROLOGY, 2012, 8 (04) : 401 - 404
[7] Severe ureteropelvic junction obstruction with massive hydronephrosis causing compression of the inferior vena cava
Asanad, Kian
Nassiri, Nima
Vasquez, Evalynn
UROLOGY CASE REPORTS, 2020, 32
[8] Surgical Approaches to Pediatric Ureteropelvic Junction Obstruction
Tubre, Ryan W.
Gatti, John M.
CURRENT UROLOGY REPORTS, 2015, 16 (10)
[9] Management of Severe Bilateral Ureteropelvic Junction Obstruction in Neonates with Prenatally Diagnosed Bilateral Hydronephrosis
Kim, Jongwon
Hong, Sungwoo
Park, Chang Hoo
Park, Hongzoo
Kim, Kun Suk
KOREAN JOURNAL OF UROLOGY, 2010, 51 (09) : 653 - 656
[10] Giant hydronephrosis secondary to ureteropelvic junction obstruction in adults: report of a case and review of literatures
Hu, Guanghui
Luo, Min
Xu, Yunfei
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (03): : 4715 - 4717

← 1 2 3 4 5 →