Synthesis of Spirocyclic-1,2-Benzisothiazoles by Rh(III)-Catalyzed [4+1] Annulation of Sulfoximines with Maleimides

被引：0

作者：

Kumar, Anil ^{[1
]}

Reddy, Sudharshan Nagabhushana ^{[1
]}

Hanchate, Vinayak ^{[1
]}

Prabhu, Kandikere Ramaiah ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 14卷 / 01期

关键词：

Spirocyclic-1,2-benzisothiazole; 4+1] annulation; Sulfoximine; Maleimide; Rh(III)-catalyst; BENZOTHIAZOLE; ANALOGS; AGENTS;

D O I：

10.1002/ajoc.202400537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rh(III)-catalyzed spiro-annulation of sulfoximines with maleimides leads to the diastereoselective synthesis of spirocyclic-1,2-benzisothiazole heterocycles is disclosed here. This strategy rapidly assembles five-membered sulfur-nitrogen-containing spirocyclic molecules in one-step. Moreover, the method is scalable and exhibits favourable diastereoselectivity, moderate functional group tolerance, and excellent site-selectivity.

引用

页数：5

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