An update on the role of focused ultrasound in neuro-oncology

被引：1

作者：

Epstein, Jordan E. ^{[1
,2
]}

Pople, Christopher B. ^{[1
,2
]}

Meng, Ying ^{[1
,2
]}

Lipsman, Nir ^{[1
,2
]}

机构：

[1] Univ Toronto, Harquail Ctr Neuromodulat, Toronto, ON, Canada

[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Neurosurg, Toronto, ON, Canada

来源：

CURRENT OPINION IN NEUROLOGY | 2024年 / 37卷 / 06期

关键词：

blood-brain barrier; brain tumors; focused ultrasound; liquid biopsy; tumor ablation; BLOOD-BRAIN-BARRIER; NONTHERMAL ABLATION; RADIATION-THERAPY; CONTRAST AGENTS; GLIOBLASTOMA; TUMORS; HISTOTRIPSY; DELIVERY; HYPERTHERMIA; RADIOTHERAPY;

D O I：

10.1097/WCO.0000000000001314

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of reviewBrain tumor treatment presents challenges for patients and clinicians, with prognosis for many of the most common brain tumors being poor. Focused ultrasound (FUS) can be deployed in several ways to circumvent these challenges, including the need to penetrate the blood-brain barrier and spare healthy brain tissue. This article reviews current FUS applications within neuro-oncology, emphasizing ongoing or recently completed clinical trials.Recent findingsMost clinical interest in FUS for neuro-oncology remains focused on exploring BBB disruption to enhance the delivery of standard-of-care therapeutics. More recently, the application of FUS for radiosensitization, liquid biopsy, and sonodynamic therapy is garnering increased clinical attention to assist in tumor ablation, early detection, and phenotypic diagnosis. Preclinical studies show encouraging data for the immunomodulatory effects of FUS, but these findings have yet to be tested clinically.SummaryFUS is a burgeoning area of neuro-oncology research. Data from several forthcoming large clinical trials should help clarify its role in neuro-oncology care.

引用

页码：682 / 692

页数：11

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