Gold nanorods coated with self-assembled silk fibroin for improving their biocompatibility and facilitating targeted photothermal-photodynamic cancer therapy

被引:0
|
作者
Wang, Jie [1 ,2 ]
Jin, Na [1 ,2 ]
Xie, Zheyu [1 ,2 ]
Cheng, Qichao [1 ,2 ]
Jiang, Bo [1 ,2 ]
Shuai, Yajun [1 ,2 ]
Xu, Zongpu [1 ,2 ]
Wan, Quan [1 ,2 ]
Chen, Yuyin [1 ,2 ]
Mao, Chuanbin [2 ]
Yang, Mingying [1 ,2 ]
机构
[1] Zhejiang Univ, Inst Appl Bioresource Res, Coll Anim Sci, Zhejiang Prov Key Lab Utilizat & Innovat Silkworm, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China
[2] Chinese Univ Hong Kong, Dept Biomed Engn, Sha Tin, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
SURFACE-CHEMISTRY; CELLULAR UPTAKE; INFRARED LIGHT; NANOPARTICLES; PEPTIDE; TOXICITY; CYTOTOXICITY; NANOSPHERES; STABILITY; EXCHANGE;
D O I
10.1039/d4nr03641g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Gold nanorods (AuNRs) have shown great potential as photothermal agents for cancer therapy. However, the biosafety of AuNRs ordinarily synthesized using a cationic ligand assistance procedure has always been a subject of controversy, which limits their application in tumor therapy. In this study, we propose a novel strategy to enhance the biocompatibility of AuNRs by constructing a biological coating derived from silk fibroin (SF) on their surface. The SF coating could be easily and precisely manipulated using a layer-by-layer (LBL) assembly method. The resulting SF-coated gold nanorods (AuNRs@SF) exhibited reduced cytotoxicity and improved hemocompatibility compared to untreated AuNRs. Moreover, the treated nanorods were easily modified with a tumor-targeting peptide (AuNRs@MTSF) and efficiently loaded indocyanine green (ICG). Both in vitro and in vivo analyses demonstrated that AuNRs@MTSF could more effectively reach tumor tissue and enter MCF-7 cells. Furthermore, after loading ICG, AuNRs@MTSF exhibited superior antitumor efficacy compared to other groups by combining photodynamic therapy (PDT) with photothermal therapy (PTT) under near-infrared (NIR) irradiation without inducing any side effects. This work suggests that SF coating of gold nanorods is a potential approach for improving their biocompatibility, and that function-modified AuNRs@SF are effective nanoplatforms for targeted and multimodal tumor therapy.
引用
收藏
页码:4624 / 4635
页数:12
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