Impacts of Plu kaow (Houttuynia cordata Thunb.) Ethanolic Extract on Diabetes and Dyslipidemia in STZ Induced Diabetic Rats: Phytochemical Profiling, Cheminformatics Analyses, and Molecular Docking Studies

被引:2
|
作者
Rahman, Shaikh Shahinur [1 ,2 ]
Klamrak, Anuwatchakij [1 ]
Nopkuesuk, Napapuch [1 ]
Nabnueangsap, Jaran [3 ]
Janpan, Piyapon [1 ]
Choowongkomon, Kiattawee [4 ]
Daduang, Jureerut [5 ]
Daduang, Sakda [1 ,6 ]
机构
[1] Khon Kaen Univ, Fac Pharmaceut Sci, Div Pharmacognosy & Toxicol, Khon Kaen 40002, Thailand
[2] Islamic Univ, Fac Biol Sci, Dept Appl Nutr & Food Technol, Kushtia 7003, Bangladesh
[3] Mahidol Univ, Res Management & Dev Div, Salaya Cent Instrument Facil RSPG, Off President, Nakhon Pathom 73170, Thailand
[4] Kasetsart Univ, Fac Sci, Dept Biochem, Bangkok 10900, Thailand
[5] Khon Kaen Univ, Fac Associated Med Sci, Dept Clin Chem, Khon Kaen 40002, Thailand
[6] Khon Kaen Univ, Prot & Prote Res Ctr Commercial & Ind Purposes Pro, Khon Kaen 40002, Thailand
关键词
Plu kaow; Houttuynia cordata; diabetes; hyperlipidemia; molecular docking; cheminformatics; phytochemical profiling; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; QUERCETIN; MECHANISMS; AMYLASE; HYPERGLYCEMIA; ANTIOXIDANT; LIPOPROTEIN; ACTIVATION; FLAVONOIDS;
D O I
10.3390/antiox13091064
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The increasing prevalence of diabetes and dyslipidemia poses significant health challenges, impacting millions of people globally and leading to high rates of illness and death. This study aimed to explore the potential antidiabetic and hypolipidemic effects of Plu kaow (Houttuynia cordata Thunb.) ethanolic extract (PK) in streptozotocin (STZ) induced diabetic rats, focusing on its molecular mechanisms. Diabetes was induced in fasting Long Evans rats using streptozotocin (65 mg/kg b. w.), with glibenclamide (5 mg/kg/day) used as the standard experimental drug. The treated groups received oral supplementation of PK (500 mg/kg/day) for 28 days. The study evaluated blood glucose levels, lipid status, body weight, liver, kidney, and heart function biomarkers, antioxidant activity, and histological examination of various organs. Additionally, untargeted metabolomics, cheminformatics, and molecular docking were employed to elucidate the probable mechanisms of action of PK. Based on metabolomic profiling data, the PK was found to contain various putative antidiabetic agents such as kaempferol 7-neohesperidoside, isochlorogenic acid C, rutin, datiscin, and diosmin and they have been proposed to significantly (p < 0.001) reduce blood glucose levels and modulated hyperlipidemia. PK also improved the tested liver, kidney, and heart function biomarkers and reversed damage to normal pancreatic, liver, kidney, and heart cells in histological analysis. In conclusion, PK shows promise as a potential treatment or management option for diabetes and hyperlipidemia, as well as their associated complications in diabetic rats.
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页数:43
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