Photocatalytic E → Z isomerization of gem-bromofluoroalkenes: stereoselective synthesis of β-fluorostyrene derivatives

被引：0
|
作者：
Kato, Hayato [1 ]
Kayaki, Yoshihito [2 ]
Koike, Takashi [1 ]
机构：
[1] Nippon Inst Technol, Fac Fundamental Engn, Dept Appl Chem, 4-1 Gakuendai,Miyashiro Machi, Saitama 3458501, Japan
[2] Inst Technol Tokyo, Sch Mat & Chem Technol, Dept Chem Sci & Engn, 2-12-1-E4-1 Ookayama,Meguro Ku, Tokyo 1528552, Japan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 06期
基金：
日本学术振兴会;
关键词：
DIPEPTIDYL-PEPTIDASE-IV; HIGH E/Z RATIO; FLUOROALKENES; DIFLUOROALKENES; ACCESS; MIMICS;
D O I：
10.1039/d4ob01658k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereoselective synthesis of beta-fluorostyrene derivatives has been achieved. Selective isomerization of gem-bromofluoroalkenyl benzenes bearing various ortho-substituents is enabled by using Ir photocatalysts with high triplet energy. Subsequent one-pot transition-metal (TM)-catalyzed reactions enable pot-economical synthesis of monofluoroalkenes in a stereoselective manner.
引用
收藏
页码：1342 / 1346
页数：5
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