An overview of the current evidences on the role of iron in colorectal cancer: a review

被引：1

作者：

Yousefi, Mohammad Hasan ^{[1
,2
]}

Masoudi, Alireza ^{[3
]}

Saberi Rounkian, Masoumeh ^{[4
]}

Mansouri, Maryam ^{[5
]}

Hojat, Bita ^{[6
]}

Kaveh Samani, Marzieh ^{[5
]}

Veisi, Razieh ^{[5
]}

Honarvar Bakeshloo, Parisa ^{[7
]}

Nosratipour, Reza ^{[8
]}

Afkhami, Hamed ^{[2
,9
,10
]}

Saeb, Sepideh ^{[11
]}

机构：

[1] Qom Univ Med Sci, Sch Med, Dept Tissue Engn & Appl Cell Sci, Qom, Iran

[2] Qom Univ Med Sci, Cellular & Mol Res Ctr, Qom, Iran

[3] Qom Univ Med Sci, Dept Anesthesiol & Crit Care, Qom, Iran

[4] Guilan Univ Med Sci, Student Res Comm, Sch Paramedicine, Rasht, Iran

[5] Shahrekord Univ Med Sci, Student Res Comm, Shahrekord, Iran

[6] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran

[7] Babol Univ Med Sci, Sch Med, Dept Med Microbiol, Babol, Iran

[8] Islamic Azad Univ, Dept Biol, Borujard, Iran

[9] Semnan Univ Med Sci, Nervous Syst Stem Cells Res Ctr, Semnan, Iran

[10] Shahed Univ, Fac Med, Dept Med Microbiol, Tehran, Iran

[11] Birjand Univ Med Sci, Qaen Fac Med Sci, Dept Allied Med, Birjand, Iran

来源：

FRONTIERS IN ONCOLOGY | 2025年 / 15卷

关键词：

colorectal cancer; iron metabolism; heme and non-heme iron; iron therapy; blood transfusion; iron deficiency; iron overload; INTRAVENOUS FERRIC CARBOXYMALTOSE; DEFICIENCY ANEMIA; DIETARY IRON; COLON-CANCER; GENE-MUTATIONS; RISK; HEMOCHROMATOSIS; THERAPY; HEREDITARY; MANAGEMENT;

D O I：

10.3389/fonc.2025.1499094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is a common and lethal malignancy that affects millions of people worldwide. Iron is an essential micronutrient that plays a vital role in various biological processes, but also has pro-oxidant and pro-inflammatory effects that may contribute to carcinogenesis. The relationship between iron and CRC is complex and influenced by multiple factors, such as dietary intake, absorption, storage, metabolism, and excretion of iron, as well as genetic and environmental factors that modulate iron homeostasis. This review article aims to provide an overview of the current evidences on the role of iron in CRC, discussing the potential mechanisms by which iron may affect CRC development and progression, as well as the implications for prevention and treatment. This review tries to focus on the following aspects: an introduction to iron and its role in CRC, role of heme and non-heme iron in CRC, dietary patterns, nutrition, and CRC, iron overload in CRC, iron deficiency and its role in CRC especially in surgery outcome and iron therapy and blood transfusion in CRC.

引用

页数：14

共 136 条

[71] Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia [J].