Immunosenescence and inflammaging: Mechanisms and role in diseases

被引:23
作者
Ajoolabady, Amir [1 ]
Pratico, Domenico [2 ]
Tang, Daolin [3 ]
Zhou, Shuqin [4 ]
Franceschi, Claudio [5 ,6 ,7 ]
Ren, Jun [8 ,9 ]
机构
[1] Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USA
[2] Temple Univ, Alzheimers Ctr Temple, Lewis Katz Sch Med, Philadelphia, PA 19140 USA
[3] UT Southwestern Med Ctr, Dept Surg, Dallas, TX 75390 USA
[4] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Emergency, Shanghai 200072, Peoples R China
[5] IRCCS Inst Neurol Sci Bologna, Bologna, Italy
[6] Lobachevsky Univ, Dept Appl Math, Nizhnii Novgorod, Russia
[7] Lobachevsky Univ, Lab Syst Biol Aging, Nizhnii Novgorod, Russia
[8] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China
[9] Natl Clin Res Ctr Intervent Med, Shanghai 200032, Peoples R China
关键词
Immunosenescence; Inflammaging; Inflammation; Aging; Cancer; Neurodegeneration; Dementia; Infections; KILLER T-CELLS; HEMATOPOIETIC STEM-CELLS; DENDRITIC CELLS; AGED MICE; CELLULAR SENESCENCE; OXIDATIVE STRESS; PERIPHERAL-BLOOD; MACULAR DEGENERATION; SUPPRESSOR-CELLS; EPITHELIAL-CELLS;
D O I
10.1016/j.arr.2024.102540
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Age-related changes initiate a cascade of cellular and molecular alterations that lead to immune system dysfunction or abnormal activation, predisposing individuals to age-related diseases. This phenomenon, commonly referred to as immunosenescence, highlighting aging-associated progressive decline of the immune system. Moreover, mounting evidence suggests that immunosenescence contributes to a related pathological phenomenon known as inflammaging. Inflammaging refers to chronic, low-grade, and systemic inflammation associated with aging, occurring despite the absence of overt stimuli. In the body, inflammation is typically activated in response to overt stimuli such as bacterial/microbial invasion or a pathological state, however, inflammaging occurrence and its underpinning mechanisms seem to be independent and in the absence of such stimuli. Despite recent advancements in molecular characterization and the scrutiny of disease relevance, these two interconnected concepts have remained largely unexplored and unrecognized. In this comprehensive review, we aim to shed light on the mechanistic and cellular aspects of immunosenescence and inflammaging, as well as their pivotal roles in the pathogenesis of aging-related diseases, including cancer, infections, dementia, and neurodegenerative disorders.
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页数:16
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