Validation of the APOBEC3A-Mediated RNA Single Base Substitution Signature and Proposal of Novel APOBEC1, APOBEC3B, and APOBEC3G RNA Signatures

被引：1

作者：

Fixman, Benjamin

Diaz-Gay, Marcos ^{[2
,3
]}

Qiu, Connor

Margaryan, Tamara

Lee, Brian

Chen, Xiaojiang S. ^{[1
,4
,5
,6
]}

机构：

[1] Univ Southern Calif, Dept Biol Sci, Mol & Computat Biol, Los Angeles, CA 90089 USA

[2] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[4] Keck Sch Med, Genet Mol & Cellular Biol Program, Los Angeles, CA USA

[5] Norris Comprehens Canc Ctr, Los Angeles, CA USA

[6] Univ Southern Calif, Ctr Excellence NanoBiophys, Los Angeles, CA 90089 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2024年 / 436卷 / 24期

关键词：

Mutational Signatures; RNA Editing; APOBEC1; APOBEC3A; APOBEC3B; APOBEC3G; MUTATIONAL SIGNATURES; CANCER; MUTAGENESIS; EVOLUTION; DATABASE;

D O I：

10.1016/j.jmb.2024.168854

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutational signature analysis gained significant attention for providing critical insights into the underlying mutational processes for various DNA single base substitution (SBS) signatures and their associations with different cancer types. Recently, RNA single base substitution (RNA-SBS) signatures were defined and described by decomposing RNA variants found in non-small cell lung cancer. Through statistical association, they attributed Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 3A (APOBEC3A) mutagenesis to the RNA-SBS2 signature. Here, we provide the first validation of an RNA-SBS mutational signature by decomposing novel exogenous and endogenous APOBEC3A RNA editing signatures into COSMICv3.4 RNA-SBS reference signatures. Additionally, we have identified novel RNA-SBS signatures for APOBEC1, APOBEC3B, and APOBEC3G. (c) 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页数：7

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