Fiber-Dependent 3D Anisotropic Stiffness-Tunable Biomimetic Intervertebral Disc via Multi-Material Additive Manufacturing

被引:1
作者
Fan, Weiguo [1 ]
Qian, Zhihui [1 ,2 ]
Song, Guangsheng [1 ]
Wang, Kunyang [1 ,2 ]
Galbusera, Fabio [3 ]
Ren, Lei [1 ,2 ,4 ]
Wilke, Hans-Joachim [5 ]
Ren, Luquan [1 ,2 ]
机构
[1] Jilin Univ, Key Lab Bion Engn, Minist Educ, Changchun 130022, Peoples R China
[2] Liaoning Acad Mat, Inst Struct & Architected Mat, Shenyang 110167, Peoples R China
[3] Schulthess Clin, Spine Ctr, CH-8008 Zurich, Switzerland
[4] Univ Manchester, Dept Mech Aerosp & Civil Engn, Manchester M13 9PL, England
[5] Univ Ulm, Ulm Univ Med Ctr, Inst Orthopaed Res & Biomech, D-89081 Ulm, Germany
基金
中国国家自然科学基金;
关键词
3D anisotropy stiffness; biomimetic design; gradient fiber; multi-material additive manufacturing; ANTERIOR CERVICAL DISKECTOMY; ARTIFICIAL DISC; ULTRASTRUCTURAL ORGANIZATION; ELASTIC FIBERS; REPLACEMENT; DESIGN; DEGENERATION; ARTHROPLASTY; FUSION; BIOMECHANICS;
D O I
10.1002/adfm.202414275
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Lumbar intervertebral disc degeneration is a global musculoskeletal disorder. Total disc replacement is an effective treatment for symptomatic degeneration unresponsive to conservative care. However, current artificial discs, with their joint-like structural design and homogeneous materials, fail to replicate the 3D anisotropic stiffness of natural discs. Inspired by the intricate structure and material gradient of the natural disc, a biomimetic intervertebral disc is designed and fabricated using multi-material additive manufacturing. The biomimetic disc exhibits 3D anisotropic stiffness similar to natural discs. By adjusting the hardness, diameter, and arrangement of fibers in annulus fibrosus, the biomimetic disc closely matches the 3D anisotropic stiffness of the natural lumbar disc, exceeding 90% similarity and outperforming existing artificial discs. This highlights the crucial role of fiber properties in disc stiffness regulation and enhances the understanding of biomechanical functions of structures and materials in the annulus fibrosus of human discs. These insights may inspire high-performance artificial disc designs.
引用
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页数:11
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