Cuproptosis nanomedicine in cancer therapy: Novel insights and future perspectives

被引：3

作者：

Wang, Lu ^{[1
]}

Piao, Jingxuan ^{[2
,3
]}

Qi, Hengkai ^{[1
]}

Qiao, Chu ^{[1
]}

Guo, Qiqiang ^{[4
]}

Wei, Minjie ^{[1
]}

Li, Zhenhua ^{[1
]}

机构：

[1] China Med Univ, Sch Pharm, Shenyang 110122, Peoples R China

[2] China Med Univ Queens Univ Belfast Joint Coll, Shenyang 110122, Peoples R China

[3] Imperial Coll London, Dept Metab Digest & Reprod, London, England

[4] China Med Univ, Hlth Sci Inst, Coll Basic Med Sci, Shenyang 110122, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2025年 / 523卷

基金：

中国国家自然科学基金;

关键词：

Copper; Cuproptosis; Nanomedicine; Cancer therapy; Cancer immunotherapy; MOLECULAR-MECHANISMS; COPPER TRANSPORTER; OXIDATIVE STRESS; CELLS; ANGIOGENESIS; PROTEIN; GROWTH; METAL; NANOPLATFORM; HOMEOSTASIS;

D O I：

10.1016/j.ccr.2024.216284

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cuproptosis, a new type of copper-triggered programmed cell death, has recently emerged as a promising target for cancer treatment. The nanomedicine-based targeting of cuproptosis has experienced significant advancements, attracting enormous interest and opening new avenues for developing novel therapeutics. In this review, we provide a comprehensive summary of the biology of copper, its critical roles in cancer biology, and the molecular mechanisms underlying cuproptosis. We also offer insight into recent progress in nanomedicinetriggered cuproptosis, a potent and proof-of-concept application in innovative therapeutic strategies. Finally, we highlight future perspectives and challenges, including the clinical translation of cancer nanomedicine and new cuproptosis-mediated emerging paradigms.

引用

页数：18

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