Cuproptosis nanomedicine in cancer therapy: Novel insights and future perspectives

被引：3

作者：

Wang, Lu ^{[1
]}

Piao, Jingxuan ^{[2
,3
]}

Qi, Hengkai ^{[1
]}

Qiao, Chu ^{[1
]}

Guo, Qiqiang ^{[4
]}

Wei, Minjie ^{[1
]}

Li, Zhenhua ^{[1
]}

机构：

[1] China Med Univ, Sch Pharm, Shenyang 110122, Peoples R China

[2] China Med Univ Queens Univ Belfast Joint Coll, Shenyang 110122, Peoples R China

[3] Imperial Coll London, Dept Metab Digest & Reprod, London, England

[4] China Med Univ, Hlth Sci Inst, Coll Basic Med Sci, Shenyang 110122, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2025年 / 523卷

基金：

中国国家自然科学基金;

关键词：

Copper; Cuproptosis; Nanomedicine; Cancer therapy; Cancer immunotherapy; MOLECULAR-MECHANISMS; COPPER TRANSPORTER; OXIDATIVE STRESS; CELLS; ANGIOGENESIS; PROTEIN; GROWTH; METAL; NANOPLATFORM; HOMEOSTASIS;

D O I：

10.1016/j.ccr.2024.216284

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cuproptosis, a new type of copper-triggered programmed cell death, has recently emerged as a promising target for cancer treatment. The nanomedicine-based targeting of cuproptosis has experienced significant advancements, attracting enormous interest and opening new avenues for developing novel therapeutics. In this review, we provide a comprehensive summary of the biology of copper, its critical roles in cancer biology, and the molecular mechanisms underlying cuproptosis. We also offer insight into recent progress in nanomedicinetriggered cuproptosis, a potent and proof-of-concept application in innovative therapeutic strategies. Finally, we highlight future perspectives and challenges, including the clinical translation of cancer nanomedicine and new cuproptosis-mediated emerging paradigms.

引用

页数：18

共 119 条

[101] Role of Copper in Angiogenesis and Its Medicinal Implications [J].

Xie, Huiqi ;

Kang, Y. James .

CURRENT MEDICINAL CHEMISTRY, 2009, 16 (10) :1304-1314

[102] Cuproptosis: mechanisms and links with cancers [J].

Xie, Jiaming ;

Yang, Yannan ;

Gao, Yibo ;

He, Jie .

MOLECULAR CANCER, 2023, 22 (01)

[103] CircRNAs in anticancer drug resistance: recent advances and future potential [J].

Xu, Tianwei ;

Wang, Mengwei ;

Jiang, Lihua ;

Ma, Li ;

Wan, Li ;

Chen, Qinnan ;

Wei, Chenchen ;

Wang, Zhaoxia .

MOLECULAR CANCER, 2020, 19 (01)

[104] Tumor Microenvironment Responsive Hollow Nanoplatform for Triple Amplification of Oxidative Stress to Enhance Cuproptosis-Based Synergistic Cancer Therapy [J].

Xu, Weijun ;

Wang, Yaping ;

Hou, Guanghui ;

Wang, Jinlei ;

Wang, Taibing ;

Qian, Junmin ;

Suo, Aili .

ADVANCED HEALTHCARE MATERIALS, 2023, 12 (13)

[105] A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms [J].

Xu, Weijun ;

Qian, Junmin ;

Hou, Guanghui ;

Wang, Taibing ;

Wang, Jinlei ;

Wang, Yaping ;

Yang, Lijun ;

Cui, Xinke ;

Suo, Aili .

ADVANCED FUNCTIONAL MATERIALS, 2022, 32 (40)

[106] An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-Based Synergistic Cancer Therapy [J].

Xu, Yuzhi ;

Liu, Si-Yang ;

Zeng, Leli ;

Ma, Hansu ;

Zhang, Yanfei ;

Yang, Huihui ;

Liu, Yuchen ;

Fang, Shuo ;

Zhao, Jing ;

Xu, Yunsheng ;

Ashby, Charles R. ;

He, Yulong ;

Dai, Zong ;

Pan, Yihang .

ADVANCED MATERIALS, 2022, 34 (43)

[107] Copper-dependent autophagic degradation of GPX4 drives ferroptosis [J].

Xue, Qian ;

Yan, Ding ;

Chen, Xi ;

Li, Xiaofen ;

Kang, Rui ;

Klionsky, Daniel J. J. ;

Kroemer, Guido ;

Chen, Xin ;

Tang, Daolin ;

Liu, Jinbao .

AUTOPHAGY, 2023, 19 (07) :1982-1996

[108] In-situ fabrication of novel Au nanoclusters-Cu2+@sodium alginate/hyaluronic acid nanohybrid gels for cuproptosis enhanced photothermal/photodynamic/chemodynamic therapy via tumor microenvironment regulation [J].

Yang, Zheng ;

Zhao, Zhou ;

Cheng, Hanlong ;

Shen, Yuhua ;

Xie, Anjian ;

Zhu, Manzhou .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2023, 641 :215-228

[109] Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer [J].

Zhang, Huijuan ;

Chen, Fangmin ;

Cheng, Wenhao ;

Lai, Yi ;

Hou, Bo ;

Shan, Yiming ;

Qu, Xiongwei ;

Xu, Zhi Ping ;

Xu, Zhiai ;

Hu, Xiuli ;

Yu, Haijun .

NANO TODAY, 2024, 58

[110] Syphilis mimetic nanoparticles for cuproptosis-based synergistic cancer therapy via reprogramming copper metabolism [J].

Zhang, Jingzhe ;

Han, Maosen ;

Zhang, Jing ;

Abdalla, Mohnad ;

Sun, Peng ;

Yang, Zhenmei ;

Zhang, Cai ;

Liu, Ying ;

Chen, Chen ;

Jiang, Xinyi .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 640

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