Anti-MDA5 positivity: describing the frequency and spectrum of clinically evident MDA5 disease

被引：1

作者：

See, Janelle ^{[1
]}

Fairley, Jessica L. ^{[1
,3
]}

Yeo, Ai L. ^{[1
,4
]}

Ojaimi, Samar ^{[2
,4
]}

Morand, Eric F. ^{[1
,4
]}

机构：

[1] Monash Hlth, Dept Rheumatol, Melbourne, Vic, Australia

[2] Monash Hlth, Monash Pathol, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[4] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2024年 / 54卷 / 12期

关键词：

MDA5; disease; dermatomyositis; interstitial lung disease; rapidly progressive ILD; tofacitinib; INTERSTITIAL LUNG-DISEASE; JAPANESE PATIENTS; DERMATOMYOSITIS; ANTIBODY; AUTOANTIBODIES; CADM-140; MYOSITIS; ADULT; RISK;

D O I：

10.1111/imj.16563

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate experience in a tertiary rheumatology service with melanoma differentiation-association-protein-5 (MDA5) disease and testing, patients with positive autoantibody results were reviewed for the presence of clinical disease. Anti-MDA5 positivity was detected in 2% of myositis-specific antibody tests. Of these, 29% did not have features consistent with anti-MDA5 disease. However, when present, MDA5 disease is severe with a high mortality.

引用

页码：2061 / 2066

页数：6

共 16 条

[1] Diagnostic performance of a commercial immunoblot assay for myositis antibody testing [J].

Bundell, Chris ;

Rojana-udomsart, Arada ;

Mastaglia, Frank ;

Hollingsworth, Peter ;

McLean-Tooke, Andrew .

PATHOLOGY, 2016, 48 (04) :363-366

[2] Tofacitinib in Amyopathic Dermatomyositis-Associated Interstitial Lung Disease [J].

Chen, Zhiwei ;

Wang, Xiaodong ;

Ye, Shuang .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (03) :291-293

[3] Utility of Anti-Melanoma Differentiation-Associated Gene 5 Antibody Measurement in Identifying Patients With Dermatomyositis and a High Risk for Developing Rapidly Progressive Interstitial Lung Disease: A Review of the Literature and a Meta-Analysis [J].

Chen, Zhiyong ;

Cao, Mengshu ;

Nieves Plana, Maria ;

Liang, Jun ;

Cai, Hourong ;

Kuwana, Masataka ;

Sun, Lingyun .

ARTHRITIS CARE & RESEARCH, 2013, 65 (08) :1316-1324

[4] Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays [J].

Damoiseaux, Jan ;

Vulsteke, Jean-Baptiste ;

Tseng, Chih-Wei ;

Platteel, Anouk C. M. ;

Piette, Yves ;

Shovman, Ora ;

Bonroy, Carolien ;

Hamann, Dorte ;

De Langhe, Ellen ;

Musset, Lucille ;

Chen, Yi-Hsing ;

Shoenfeld, Yehuda ;

Allenbach, Yves ;

Bossuyt, Xavier .

AUTOIMMUNITY REVIEWS, 2019, 18 (03) :293-305

[5] Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis [J].

Daniel Rocha-Munoz, Alberto ;

Ponce-Guarneros, Manuel ;

Ivan Gamez-Nava, Jorge ;

Maria Olivas-Flores, Eva ;

Mejia, Mayra ;

Juarez-Contreras, Pablo ;

Aurora Martinez-Garcia, Erika ;

Guadalupe Corona-Sanchez, Esther ;

Marlen Rodriguez-Hernandez, Tania ;

Vazquez-del Mercado, Monica ;

Salazar-Paramo, Mario ;

Hernan Nava-Zavala, Arnulfo ;

German Cardona-Munoz, Ernesto ;

Celis, Alfredo ;

Gonzalez-Lopez, Laura .

JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015

[6] The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): A retrospective study [J].

Fiorentino, David ;

Chung, Lorinda ;

Zwerner, Jeff ;

Rosen, Antony ;

Casciola-Rosen, Livia .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2011, 65 (01) :25-34

[7] Clinical Correlations With Dermatomyositis-Specific Autoantibodies in Adult Japanese Patients With Dermatomyositis A Multicenter Cross-sectional Study [J].

Hamaguchi, Yasuhito ;

Kuwana, Masataka ;

Hoshino, Kana ;

Hasegawa, Minoru ;

Kaji, Kenzo ;

Matsushita, Takashi ;

Komura, Kazuhiro ;

Nakamura, Motonobu ;

Kodera, Masanari ;

Suga, Norihiro ;

Higashi, Akira ;

Ogusu, Koji ;

Tsutsui, Kiyohiro ;

Furusaki, Akira ;

Tanabe, Hiroshi ;

Sasaoka, Shunsuke ;

Muro, Yoshinao ;

Yoshikawa, Mika ;

Ishiguro, Naoko ;

Ayano, Masahiro ;

Muroi, Eiji ;

Fujikawa, Keita ;

Umeda, Yukihiro ;

Kawase, Masaaki ;

Mabuchi, Eriko ;

Asano, Yoshihide ;

Sodemoto, Kinuyo ;

Seishima, Mariko ;

Yamada, Hidehiro ;

Sato, Shinichi ;

Takehara, Kazuhiko ;

Fujimoto, Manabu .

ARCHIVES OF DERMATOLOGY, 2011, 147 (04) :391-398

[8] Clinical characteristics of dermatomyosits/polymyositis associated interstitial lung disease according to the autoantibody [J].

Kishaba, Tomoo ;

McGill, Rita ;

Nei, Yuichiro ;

Ibuki, Sachi ;

Momose, Masashi ;

Nishiyama, Kenta ;

Nagano, Hiroaki ;

Yamashiro, Shin .

JOURNAL OF MEDICAL INVESTIGATION, 2018, 65 (3-4) :251-257

[9] Assessment of anti-MDA5 antibody as a diagnostic biomarker in patients with dermatomyositis-associated interstitial lung disease or rapidly progressive interstitial lung disease [J].

Li, Liubing ;

Wang, Qian ;

Wen, Xiaoting ;

Liu, Chenxi ;

Wu, Chanyuan ;

Yang, Funing ;

Zeng, Xiaofeng ;

Li, Yongzhe .

ONCOTARGET, 2017, 8 (44) :76129-76140

[10] Interstitial Lung Disease and Myositis in a Patient With Antisynthetase Syndrome and PL12 and Ro52 Co-positivity in a Retired Medical Officer [J].

Loncharich, Michael F. ;

Anderson, Caleb W. ;

Collins, Jeannette ;

Edison, Jess .

MILITARY MEDICINE, 2021, 186 (7-8) :E767-E770

← 1 2 →