The association between cigarette smoking and radiographic progression in Psoriatic Arthritis

被引：0
作者：
Kharouf, Fadi [1 ,2 ]
Maldonado-Ficco, Hernan [1 ,2 ]
Gao, Shangyi [1 ]
Sheane, Barry J. [1 ,2 ]
Pereira, Daniel [1 ]
Chandran, Vinod [1 ,2 ,3 ,4 ]
Gladman, Dafna D. [1 ,2 ,3 ,5 ]
机构：
[1] Univ Hlth Network, Schroeder Arthrit Inst, Gladman Krembil Psoriat Arthrit Res Program, Ctr Prognosis Studies Rheumat Dis,Krembil Res Inst, 399 Bathurst St 1E-410B, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Dept Med, Div Rheumatol, Toronto, ON, Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[5] Univ Hlth Network, Schroeder Arthrit Inst, Ctr Prognosis Studies Rheumat Dis, Psoriat Arthrit Program, 399 Bathurst St 1E-410B, Toronto, ON M5T 2S8, Canada
来源：
SEMINARS IN ARTHRITIS AND RHEUMATISM | 2025年 / 71卷
关键词：
Psoriasis; Spondyloarthritis; Cigarette smoking; Damage; Prognosis; DISEASE-ACTIVITY; RHEUMATOID-ARTHRITIS; AXIAL SPONDYLOARTHRITIS; TOBACCO SMOKING; RISK; DAMAGE; HEALTH; CRITERIA; COHORT; TRIAL;
D O I：
10.1016/j.semarthrit.2025.152653
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: The association between smoking and radiographic damage has been established in axial spondyloarthritis and rheumatoid arthritis, but not in psoriatic disease. We aimed to investigate this relationship in psoriatic arthritis (PsA). Methods: We included patients with PsA from our observational cohort. Smoking status was assessed at each clinic visit and categorized as non-smoker, past smoker, or current smoker. We used linear mixed models to identify factors associated with the overall change in damage, as measured by the modified Steinbrocker score. Results: Of 1736 patients included in the study, 952 (54.9 %) were males; the mean (standard deviation) age at baseline was 44.9 (13.3) years. 906 (52.2 %) patients were non-smokers, 211 (12.2 %) were past smokers, and 311 (17.9 %) were current smokers; 308 (17.7 %) patients had missing smoking data. The median [interquartile range] modified Steinbrocker score at baseline was 2.0 [0.0, 10.0]. In the multivariable linear mixed model, a longer duration between the first and last sets of radiographs, a higher baseline modified Steinbrocker score, and the use of conventional synthetic DMARDs were significantly associated with an increase in joint damage. Cigarette smoking-both current (estimate-0.18, 95 % confidence interval [CI]-0.94 to 0.58) and past (estimate-0.67, 95 % CI-1.51 to 0.17)-showed no significant association with the change in modified Steinbrcoker score. Conclusion: Cigarette smoking does not appear to be significantly associated with the progression of joint damage in PsA. Further studies are required to confirm our findings.
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页数：5
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