Trends of changes in human T-cell leukemia virus type 1 epidemiology in Japan and globally

被引：0
作者：
Yoshida, Noriaki [1 ,2 ]
Hida, Ayumi [3 ]
Sakata, Ritsu [4 ]
机构：
[1] Radiat Effects Res Fdn, Dept Clin Studies, 5-2 Hijiyama Pk,Minami ku, Hirohisma 7320815, Japan
[2] Kurume Univ, Dept Pathol, Sch Med, 67 Asahi Machi, Fukuoka 8300011, Japan
[3] Radiat Effects Res Fdn, Dept Clin Studies, 8-6 Nakagawa 1-chome, Nagasaki 8500013, Japan
[4] Radiat Effects Res Fdn, Dept Epidemiol, 5-2 Hijiyama Pk,Minami ku, Hirohisma 7320815, Japan
来源：
LEUKEMIA RESEARCH | 2025年 / 150卷
关键词：
Human T-cell leukemia virus type 1; HTLV-1-associated myelopathy/tropical spastic; paraparesis; vertical transmission; horizontal transmission; prevention strategies; adult T-cell leukemia-lymphoma; I-ASSOCIATED MYELOPATHY; LYMPHOTROPIC VIRUS; HTLV-I; PREGNANT-WOMEN; BLOOD-DONORS; CHILD TRANSMISSION; PROVIRAL LOAD; INFECTION; PREVALENCE; SEROPREVALENCE;
D O I：
10.1016/j.leukres.2025.107654
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human T-cell leukemia virus type 1 (HTLV-1) has been identified as a cause of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite several HTLV-1 endemic areas being identified, comprehensive investigations have yet to be conducted in all the regions of the world. This review aims to summarize the current reports on HTLV-1. As vertical transmission is known to be a risk factor for ATL development, prevention strategies have been initiated in Japan, and these efforts may be related to the decrease in the estimated number of HTLV-1 carriers in Japan. In numerous HTLV-1 endemic regions, the prevalence of HTLV-1 increases with age, which may be attributed to horizontal infection. However, the incidence of HTLV-1 infection appears to be high among adolescents and young adults in Japan, especially in non-endemic areas. The clinical significance of HTLV-1 infections, other than ATL and HAM/TSP, has recently been documented. Consequently, it is imperative to develop treatment strategies for HTLV-1 infections, including measures to prevent horizontal infections.
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