Association of MicroRNA Expression and Serum Neurofilament Light Chain Levels with Clinical and Radiological Findings in Multiple Sclerosis

被引:0
作者
Dominguez-Mozo, Maria Inmaculada [1 ]
Casanova, Ignacio [2 ,3 ,4 ]
Monreal, Enric [5 ]
Costa-Frossard, Lucienne [5 ]
Sainz-de-la-Maza, Susana [5 ]
Sainz-Amo, Raquel [5 ]
Aladro-Benito, Yolanda [6 ]
Lopez-Ruiz, Pedro [4 ]
De-Torres, Laura [2 ]
Abellan, Sara [2 ]
Garcia-Martinez, Maria Angel [1 ]
De-la-Cuesta, David [1 ]
Lourido, Daniel [7 ]
Torrado-Carvajal, Angel [8 ]
Gomez-Barbosa, Carol [9 ]
Linares-Villavicencio, Carla [9 ]
Maria Villar, Luisa [10 ]
Lopez-De-Silanes, Carlos [2 ]
Arroyo, Rafael [4 ]
Alvarez-Lafuente, Roberto [1 ]
机构
[1] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Res Grp Environm Factors Neurodegenerat Dis, Red Enfermedades Inflamatorias REI, Madrid 28040, Spain
[2] Hosp Univ Torrejon, Dept Neurol, Madrid 28850, Spain
[3] Univ Francisco Vitoria, Sch Med, Madrid 28223, Spain
[4] Hosp Univ QuironSalud Madrid, Dept Neurol, Madrid 28223, Spain
[5] Univ Alcala, Hosp Univ Ramon & Cajal, Dept Neurol,Inst Ramon & Cajal Invest Sanitaria, Red Enfermedades Inflamatorias REI, Madrid 28034, Spain
[6] Hosp Univ Getafe, Dept Neurol, Madrid 28905, Spain
[7] Univ Alcala, Hosp Univ Ramon & Cajal, Dept Radiol, Inst Ramon & Cajal Invest Sanitaria, Madrid 28034, Spain
[8] Univ Rey Juan Carlos, Med Image Anal & Biometry Lab, Madrid 28933, Spain
[9] Hosp Univ Torrejon, Dept Radiol, Madrid 28850, Spain
[10] Univ Alcala, Hosp Univ Ramon & Cajal, Dept Immunol,Inst Ramon & Cajal Invest Sanitaria, Red Enfermedades Inflamatorias REI, Madrid 28034, Spain
关键词
multiple sclerosis; microRNAs (MiRNAs); neurofilament light (NfL); magnetic resonance imaging (MRI); processing speed test (PST); PROGRESSION; RELAPSE; MIR-126; CELLS; MODEL;
D O I
10.3390/ijms251810012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
microRNAs (miRNAs) are promising biomarkers for many diseases, including multiple sclerosis (MS). The neurofilament light chain (NfL) is a biomarker that can detect axonal damage in different neurological diseases. The objective of this study was to evaluate the association of the expression profile of pre-selected miRNAs and NfL levels with clinical and radiological variables in MS patients. We conducted a 1-year longitudinal prospective study in MS patients with different clinical forms. We measured clinical disability using the expanded disability status scale (EDSS), the magnetic resonance imaging (MRI) volumetry baseline, and cognitive functioning using the processing speed test (PST) at baseline and 1 year later. Selected serum miRNAs and serum NfL (sNfL) levels were quantified. Seventy-three patients were recruited. MiR-126.3p correlated with EDSS and cognitive status at baseline and miR-126.3p and miR-9p correlated with cognitive deterioration at 1 year. Correlations with regional brain volumes were observed between miR-126.3p and the cortical gray matter, cerebellum, putamen, and pallidum; miR-146a.5p with the cerebellum and pallidum; miR-29b.3p with white matter and the pallidum; miR-138.5p with the pallidum; and miR-9.5p with the thalamus. sNfL was correlated with miR-9.5p. miR-146a.5p was also associated with the MS phenotype. These data justify future studies to further explore the utility of miRNAs (mirR-126.3p, miR-146.5p, and miR.9-5p) and sNfL levels as biomarkers of MS.
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页数:11
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