Organotin(IV) complexes anchored on the magnetic UiO-66-NH2 metal-organic framework: Synthesis and evaluation of cytotoxicity

The magnetic metal-organic framework nanocomposite Fe3O4@UiO-66-NH2 was prepared and reacted first with 5, 5 '-methylene bis-salicylicaldehyde and then benzhydrazide. In this way, a hydrazone ligand is loaded on the nanocomposite. This functionalized magnetic MOF was reacted with R2SnCl2 (R = Ph, Me) in the presence of triethylamine; thus organotin(IV) complex was immobilized on nanostructures (Fe3O4@UiO-66-SnR2). In order to increase cellular uptake, MOF-based magnetic nanocomposites carrying organotin(IV) complex were also modified by folic acid (Fe3O4@UiO-66-SnR2-FA). All synthesized nanomaterials were characterized using FT-IR, FE-SEM, HRTEM, EDX, XRD, VSM, and TGA techniques. Then, the in vitro cytotoxicity of nanocomposites as well as free hydrazonic ligand and organotin(IV) complexes were evaluated against HT-29, A549 and Hela cell lines using the MTT method. Based on the results, folate-modified targeted systems show more cytotoxic activity than others, and the highest activity was observed for Fe3O4@UiO-66-SnPh2-FA against HeLa cells.