Efficacy of Topical Treatment of Low-Risk Cervical Preinvasive Lesions with Glycyrrhizinic Acid

被引:0
作者
Andzane, Diana [1 ,2 ,3 ,4 ]
Zodzika, Jana [1 ,2 ]
Jermakova, Irina [1 ]
Senfelde, Ilva [1 ]
Utorova, Marina [1 ]
Rezeberga, Dace [1 ,2 ,3 ]
机构
[1] Riga East Clin Univ Hosp, Gynaecol Clin, Hipokrata St 2, LV-1079 Riga, Latvia
[2] Riga Stradins Univ, Dept Obstet & Gynaecol, Miera St 45, LV-1013 Riga, Latvia
[3] Riga Matern Hosp, Miera St 45, LV-1013 Riga, Latvia
[4] Riga Stradins Univ, Dept Clin Skills & Med Technol, Anninmuizas Bulvaris 26A, LV-1067 Riga, Latvia
关键词
cervical intraepithelial neoplasia; human papillomavirus; glycyrrhizinic acid; colposcopy; cervical precancerous disease; INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS; INFECTION; WOMEN;
D O I
10.3390/jcm14010136
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Objectives: The study aimed to investigate the efficacy of medication treatment with glycyrrhizinic acid for cervical intraepithelial neoplasia (CIN) 1 lesions. Methods: Women with histologically confirmed CIN 1 in cervical biopsies were included in the prospective study. Participants of the study group used glycyrrhizinic acid spray (Epigen spray) topically 10 days (Epigen 10-day subgroup) or 20 days (Epigen 20-day subgroup) per month for 6 months. Women in the control group had no treatment. There were two follow-up visits 6 months apart. All patients were screened for human papillomavirus (HPV) before enrollment and during the first follow-up visit. Results: There were 50 patients in the Epigen group and 50 patients in the control group. At the first follow-up visit, in the histological findings, progression to CIN 2+ was 6.7% in the Epigen 20-day subgroup, 31.1% in the control group, and the persistence of CIN 1 was 86.7% in the Epigen 20-day subgroup and 62.2% in the control group, p = 0.03. Large loop excision of the transformation zone (LLETZ) was statistically significantly more frequent in the control group after the first follow-up visit (10% in the Epigen 20-day subgroup vs. 30% in the control group, p = 0.032). No such relationships were found during the second follow-up visit. Conclusions: The vaginal spray of the glycyrrhizinic acid used 20 days per month appears to decrease the risk of the progression of CIN 1 lesions, with the need to perform LLETZ. However, a similar effect is not observed after stopping usage.
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