Breast Cancer Specificities of Patients With Anti-Ri Paraneoplastic Neurologic Syndromes

被引：0

作者：

Peter, Elise ^{[1
,2
,3
]}

Treilleux, Isabelle ^{[4
]}

Wucher, Valentin ^{[1
,2
,3
]}

Villagran-Garcia, Macarena ^{[1
,2
,3
]}

Dumez, Pauline ^{[1
,2
,3
]}

Pissaloux, Daniel ^{[4
,5
]}

Paindavoine, Sandrine ^{[4
,5
]}

Attignon, Valery ^{[4
,5
]}

Picard, Geraldine ^{[2
]}

Rogemond, Veronique ^{[1
,2
]}

Villard, Marine ^{[2
]}

Tonon, Laurie ^{[6
]}

Ferrari, Anthony ^{[6
]}

Viari, Alain ^{[6
]}

Dubois, Bertrand ^{[7
,8
]}

Honnorat, Jerome ^{[1
,2
,3
]}

Desestret, Virginie ^{[1
,2
,3
]}

机构：

[1] CNRS, SynatAc Team, INSERM, UMR 5284,MeLis Inst,U1314, Lyon, France

[2] Hosp Civils Lyon, French Reference Ctr Paraneoplast Neurol Syndrome, Lyon, France

[3] Univ Claude Bernard Lyon 1, Univ Lyon, Villeurbanne, France

[4] Ctr Leon Berard Unicanc, Ctr Leon Berard, Lyon, France

[5] Ctr Leon Berard, Dept Translat Res, Canc Genom Platform, Lyon, France

[6] Ctr Leon Berard, Synergie Lyon Canc, Gilles Thomas Bioinformat Platform, F-69008 Lyon, France

[7] Univ Claude Bernard Lyon 1, Univ Lyon, Canc Res Ctr Lyon, Ctr Leon Berard,INSERM 1052,CNRS 5286, Villeurbanne, France

[8] Lab Immunotherapie Canc Lyon LICL, Lyon, France

来源：

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2025年 / 12卷 / 02期

关键词：

NODE STATUS; TUMOR;

D O I：

10.1212/NXI.0000000000200367

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and ObjectivesBreast cancers (BCs) of patients with paraneoplastic neurologic syndromes and anti-Yo antibodies (Yo-PNS) overexpress human epidermal growth factor receptor 2 (HER2) and display genetic alterations and overexpression of the Yo-onconeural antigens. They are infiltrated by an unusual proportion of B cells. We investigated whether these features were also observed in patients with PNS and anti-Ri antibodies (Ri-PNS).MethodsUsing clinicopathologic data, DNA sequencing, and whole-transcriptome analysis, 28 BCs associated with Ri-PNS were characterized regarding oncological characteristics. Genetic alteration of the onconeural antigens and differential gene expression profiles were analyzed in the 12 available tumor samples and compared with those of 5 Yo-PNS tumors.ResultsRi-PNS BCs were mainly luminal B invasive carcinomas that did not overexpress HER2 and were a subtype of BCs different from the ones observed in Yo-PNS BCs. They had a low expression of wild-type TP53 and deletions of 1p chromosome. Neither overexpression nor genetic alteration of the Ri onconeural antigens was found in Ri-PNS BCs. Conversely, the nature of the antitumor immune reaction in Ri-PNS BCs was similar to the one found in Yo-PNS BCs. Ri-BCs also had a high propension for early nodal regional metastasis.DiscussionBCs associated with Ri-PNS are uncommon and the tumor subtype and their molecular and oncological characteristics are different from those of Yo-PNS and controls. Overexpression or sequence variation in the gene of the onconeural antigen is not mandatory. Conversely, Ri-PNS-associated and Yo-PNS-associated BCs display the same atypical B-cell-mediated intratumoral immune response, and tumor escape in the lymph nodes is frequent.

引用

页数：10