KIDNEY TRANSPLANTATION FROM DECEASED DONORS WITH PROSTATE CANCER

Introduction: Kidney transplantation is associated with the risk of unrecognized cancer transmission from donor to recipient. There have been no reported cases of prostate cancer transmission in kidney transplantation. Methods: We conducted a retrospective search of all cadaveric kidney allograft donors from August 2007 to November 2022 with available autopsy findings. Our primary interest were patients diagnosed with prostate cancer on autopsy. In further analysis, we recorded the data from the recipients of these kidneys, including further management and malignant disease development. Results: Overall, there were 1360 kidney transplantations at our center in the studied period. Three donors were diagnosed with prostate cancer at autopsy. Two recipients received kidney allografts from donors with a Gleason score 6 for intraprostatic cancer and one from a donor with a Gleason score of 7. After the appropriate information, all recipients decided to continue renal replacement with transplanted organs. Patients were switched to an mTOR inhibitor and are currently in regular and meticulous follow-up. Conclusion: Prostate cancer may be diagnosed on autopsy, and its prevalence has been increasing with the age of donors. The risk of transmission should be individually assessed based on the pathology findings.