Therapeutic potential of CD20/CD3 bispecific antibodies in the treatment of autoimmune diseases

被引：0

作者：

Huang, Hongpeng ^{[1
]}

Wei, Xuetao ^{[2
,3
]}

机构：

[1] Sinocelltech Ltd, Dept Bioact, Beijing 100176, Peoples R China

[2] Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China

[3] Beijing Key Lab Toxicol Res & Risk Assessment Food, Beijing 100191, Peoples R China

来源：

RHEUMATOLOGY AND IMMUNOLOGY RESEARCH | 2025年 / 5卷 / 04期

关键词：

CD20/CD3 bispecific antibody; autoimmune diseases; B-CELL DEPLETION; ANTI-CD20; LUPUS; RITUXIMAB; PREVENTS; EFFICACY;

D O I：

10.1515/rir-2024-0029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases arise from immune system dysfunction that immune cells mistakenly attack the body's own tissues, resulting in systemic disorders or localized lesions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Autoreactive B cells play a critical role in the pathogenesis of many autoimmune diseases and B cell depletion using anti-CD20 monoclonal antibody (mAb) has been shown to effectively mitigate disease progression in both preclinical and clinical studies. Recently, bispecific antibody (bsAb) targeting CD20/CD3 have demonstrated substantial clinical benefits in the treatment of various hematologic malignancies. Given their similar B cell cytotoxic mechanism, CD20/CD3 bsAb therapy may offer significant improvements in the management of many autoimmune diseases, providing a novel therapeutic option for patients. This concise review aims to summarize recent findings on CD20/CD3 bsAbs and discuss their potential in treating autoimmune diseases.

引用

页码：209 / 216

页数：8

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