BiomedRAG: A retrieval augmented large language model for biomedicine

被引:0
|
作者
Li, Mingchen [1 ]
Kilicoglu, Halil [2 ]
Xu, Hua [3 ]
Zhang, Rui [1 ]
机构
[1] Univ Minnesota, Dept Surg, Div Computat Hlth Sci, Minneapolis, MN 55455 USA
[2] Univ Illinois, Sch Informat Sci, Champaign, IL USA
[3] Yale Univ, Sch Med, Dept Biomed Informat & Data Sci, New Haven, CT USA
基金
美国国家卫生研究院;
关键词
Retrieval-augmented generation; Large language model; EXTRACTION;
D O I
10.1016/j.jbi.2024.104769
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Retrieval-augmented generation (RAG) involves a solution by retrieving knowledge from an established database to enhance the performance of large language models (LLM). , these models retrieve information at the sentence or paragraph level, potentially introducing noise and affecting the generation quality. To address these issues, we propose a novel BiomedRAG framework that directly feeds automatically retrieved chunk-based documents into the LLM. Our evaluation of BiomedRAG across four biomedical natural language processing tasks using eight datasets demonstrates that our proposed framework not only improves the performance by 9.95% on average, but also achieves state-of-the-art results, surpassing various baselines by 4.97%. BiomedRAG paves the way for more accurate and adaptable LLM applications in the biomedical domain.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Improving large language model applications in biomedicine with retrieval-augmented generation: a systematic review, meta-analysis, and clinical development guidelines
    Liu, Siru
    Mccoy, Allison B.
    Wright, Adam
    JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2025, 32 (04) : 605 - 615
  • [2] Retrieval-Augmented Generation Approach: Document Question Answering using Large Language Model
    Muludi, Kurnia
    Fitria, Kaira Milani
    Triloka, Joko
    Sutedi
    INTERNATIONAL JOURNAL OF ADVANCED COMPUTER SCIENCE AND APPLICATIONS, 2024, 15 (03) : 776 - 785
  • [3] Injury degree appraisal of large language model based on retrieval-augmented generation and deep learning
    Zhang, Fan
    Luo, Yifang
    Gao, Zihuan
    Han, Aihua
    INTERNATIONAL JOURNAL OF LAW AND PSYCHIATRY, 2025, 100
  • [4] Implementing large language model and retrieval augmented generation to extract geographic locations of illicit transnational kidney trade
    Wang, Zifu
    Li, Meng-Hao
    Baxter, Patrick
    Zhorayev, Olzhas
    Wei, Jiaxin
    Kovacs, Valerie
    Zhao, Qiuhan
    Yang, Chaowei
    Koizumi, Naoru
    INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS, 2025, 24 (01):
  • [5] Hallucination Mitigation for Retrieval-Augmented Large Language Models: A Review
    Zhang, Wan
    Zhang, Jing
    MATHEMATICS, 2025, 13 (05)
  • [6] Application of retrieval-augmented generation for interactive industrial knowledge management via a large language model
    Chen, Lun-Chi
    Pardeshi, Mayuresh Sunil
    Liao, Yi-Xiang
    Pai, Kai-Chih
    COMPUTER STANDARDS & INTERFACES, 2025, 94
  • [7] ChatENT: Augmented Large Language Model for Expert Knowledge Retrieval in Otolaryngology-Head and Neck Surgery
    Long, Cai
    Subburam, Deepak
    Lowe, Kayle
    dos Santos, Andre
    Zhang, Jessica
    Hwang, Sang
    Saduka, Neil
    Horev, Yoav
    Su, Tao
    Cote, David W. J.
    Wright, Erin D.
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2024, 171 (04) : 1042 - 1051
  • [8] Large language model for interpreting research policy using adaptive two-stage retrieval augmented fine-tuning method
    Ren, Runtao
    Ma, Jian
    Zheng, Zhimin
    EXPERT SYSTEMS WITH APPLICATIONS, 2025, 278
  • [9] Enhancing Financial Sentiment Analysis via Retrieval Augmented Large Language Models
    Zhang, Boyu
    Yang, Hongyang
    Zhou, Tianyu
    Babar, Ali
    Liu, Xiao-Yang
    PROCEEDINGS OF THE 4TH ACM INTERNATIONAL CONFERENCE ON AI IN FINANCE, ICAIF 2023, 2023, : 349 - 356
  • [10] Retrieval-Augmented Generation-aided causal identification of aviation accidents: A large language model methodology
    Ren, Tengfei
    Zhang, Zhipeng
    Jia, Bo
    Zhang, Shiwen
    EXPERT SYSTEMS WITH APPLICATIONS, 2025, 278