Metabolic targets in cardiac aging and rejuvenation

被引：2

作者：

Liu, Chang ^{[1
,2
]}

Zhang, Xiao ^{[1
,2
]}

Hu, Meiyu ^{[1
,2
]}

Lu, Yi ^{[1
]}

Gokulnath, Priyanka ^{[3
,4
]}

Vulugundam, Gururaja ^{[5
]}

Xiao, Junjie ^{[1
,2
]}

机构：

[1] Shanghai Univ, Affiliated Nantong Hosp, Inst Geriatr, Peoples Hosp Nantong 6,Sch Med, Nantong 226011, Peoples R China

[2] Shanghai Univ, Inst Cardiovasc Sci, Shanghai Engn Res Ctr Organ Repair, Cardiac Regenerat & Ageing Lab,Sch Life Sci, 333 Nan Chen Rd, Shanghai 200444, Peoples R China

[3] Massachusetts Gen Hosp, Cardiovasc Div, Boston, MA 02114 USA

[4] Harvard Med Sch, Boston, MA 02114 USA

[5] Natl Res Council Italy, Inst Biochem & Cellular Biol, I-80131 Naples, Italy

来源：

JOURNAL OF CARDIOVASCULAR AGING | 2022年 / 2卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Cardiac aging; metabolic imbalance; mitochondria dysfunction; anti-aging therapy; ACTIVATED PROTEIN-KINASE; FATTY-ACID OXIDATION; HEART-FAILURE; LIFE-SPAN; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; NICOTINAMIDE RIBOSIDE; CELLULAR MECHANISMS; IMPROVES HEALTH; RECEPTOR-ALPHA;

D O I：

10.20517/jca.2022.31

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac aging is accompanied by progressive loss of cellular function, leading to impaired heart function and heart failure. There is an urgent need for efficient strategies to combat this age-related cardiac dysfunction. A growing number of events suggest that age-related cardiac diseases are tightly related to metabolic imbalance. This review summarizes recent findings concerning metabolic changes during cardiac aging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging.

引用

页数：16

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