Hyaluronic acid and erbium laser for the treatment of genitourinary syndrome of menopause

被引:0
作者
Fidecicchi, Tiziana [1 ]
Gambacciani, Marco [2 ]
机构
[1] Pisa Univ Hosp, Dept Obstet & Gynecol, Pisa, Italy
[2] San Rossore Clin Ctr, Menopause & Osteoporosis Unit, Viale Cascine,152-F, I-56122 Pisa, Italy
关键词
Erbium laser; genitourinary syndrome of menopause; vaginal hyaluronic acid; dyspareunia; VULVO-VAGINAL ATROPHY; 2ND-GENERATION THERMOTHERAPY; SEXUAL FUNCTION; SAFETY; EFFICACY; THERAPY; WOMEN; TERM;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: This study aimed to evaluate the effect of the vaginal erbium laser (VEL) in association with vaginal hyaluronic acid (HA) in postmenopausal women suffering from genitourinary syndrome of menopause (GSM). Methods: One hundred sexually active postmenopausal women were selected and divided into three groups using a block randomization method; 10 women declined to participate. The remaining women received three laser applications at 30-day intervals; 22 women dropped out for personal reasons or protocol violations. Group 1 (n = 25) received VEL treatment (XS Fotona Smooth (R); Fotona, Slovenia) alone; Group 2 (n = 22) received daily vaginal HA tablets for 10 days after VEL treatment, followed by a twice a week administration during the follow-up period; and Group 3 (n = 21) received daily HA tablets for 10 days before the first VEL treatment and for 10 days after each laser application, followed by a twice a week administration for the follow-up period. Vaginal dryness and dyspareunia were assessed at the screening visit, before VEL treatment, after 1 and 3 months from the last laser treatment, using the visual analog scale. Data were analyzed using one-way analysis of variance and a linear mixed model for repeated measures. The post-hoc test for the interaction between time and treatment was performed using Bonferroni correction. Results: A significant (p < 0.001) improvement in both vaginal dryness and superficial dyspareunia was evident, with greater (p < 0.001) improvement in Group 2 and Group 3. Conclusions: The results suggest that vaginal HA administration can improve the VEL effects on GSM in postmenopausal women.
引用
收藏
页数:6
相关论文
共 32 条
  • [1] The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society
    不详
    [J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2020, 27 (09): : 976 - 992
  • [2] The mixed model for repeated measures for cluster randomized trials: a simulation study investigating bias and type I error with missing continuous data
    Bell, Melanie L.
    Rabe, Brooke A.
    [J]. TRIALS, 2020, 21 (01)
  • [3] Non-ablative Er:YAG laser therapy effect on stress urinary incontinence related to quality of life and sexual function: A randomized controlled trial
    Blaganje, Mija
    Scepanovic, Darija
    Zgur, Lidija
    Verdenik, Ivan
    Pajk, Franja
    Lukanovic, Adolf
    [J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2018, 224 : 153 - 158
  • [4] Vaginal atrophy across the menopausal age: results from the ANGEL study
    Cagnacci, A.
    Xholli, A.
    Sclauzero, M.
    Venier, M.
    Palma, F.
    Gambacciani, M.
    Algeri, M.
    Donvito, G.
    Bastianelli, C.
    Palma, F.
    Napolitano, A.
    Capobianco, G.
    Dessole, S.
    Cianci, A.
    Caruso, S.
    Cinque, B.
    Dati, S.
    Cioffi, G. P.
    Costantino, D.
    D'Anna, R.
    De Leo, V.
    Di Carlo, C.
    Di Francesco, A.
    Di Renzo, G.
    Baldoni, A.
    Lorefice, R.
    Ferrazzi, E.
    Valente, I.
    Gambera, A.
    Greco, P.
    Bonaccorsi, G.
    Guaschino, S.
    Tredici, Z.
    Labanchi, R.
    Chiacchio, A.
    Lanzone, A.
    Villa, P.
    Lello, S.
    Capozzi, A.
    Leo, L.
    Salvatores, M.
    Serracchioli, D. R.
    Meriggiola, C.
    Surico, N.
    Cigna, S. Zorzeti
    Zullo, F.
    Delfini, R.
    Giovannini, P.
    [J]. CLIMACTERIC, 2019, 22 (01) : 85 - 89
  • [5] Characteristics of post-menopausal women with genitourinary syndrome of menopause: Implications for vulvovaginal atrophy diagnosis and treatment selection
    Castelo-Branco, Camil
    Biglia, Nicoletta
    Nappi, Rossella E.
    Schwenkhagen, Anne
    Palacios, Santiago
    [J]. MATURITAS, 2015, 81 (04) : 462 - 469
  • [6] Evaluation of the Efficacy and Safety of Hyaluronic Acid Vaginal Gel to Ease Vaginal Dryness: A Multicenter, Randomized, Controlled, Open-Label, Parallel-Group, Clinical Trial
    Chen, Junya
    Geng, Li
    Song, Xuehong
    Li, Hongxia
    Giordan, Nicola
    Liao, Qinping
    [J]. JOURNAL OF SEXUAL MEDICINE, 2013, 10 (06) : 1575 - 1584
  • [7] Non-hormonal treatments for managing vulvovaginal atrophy/genitourinary syndrome of menopause
    Cox, P.
    Panay, N.
    [J]. CLIMACTERIC, 2023, 26 (04) : 367 - 372
  • [8] Hyaluronic Acid in Postmenopause Vaginal Atrophy: A Systematic Review
    dos Santos, Carlos Campagnaro M.
    Uggioni, Maria Laura R.
    Colonetti, Tamy
    Colonetti, Laura
    Grande, Antonio Jose
    Da Rosa, Maria Ines
    [J]. JOURNAL OF SEXUAL MEDICINE, 2021, 18 (01) : 156 - 166
  • [9] Superficial dyspareunia treatment with hyperstacking of erbium:yttrium-aluminum-garnet SMOOTH laser: a short-term, pilot study in breast cancer survivors
    Fidecicchi, Tiziana
    Gaspar, Adrian
    Gambacciani, Marco
    [J]. MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY, 2023, 30 (02): : 174 - 178
  • [10] Short-term effects of an erbium/neodymium laser combination in superficial dyspareunia: a pilot study
    Gambacciani, M.
    Fidecicchi, T.
    [J]. CLIMACTERIC, 2022, 25 (02) : 208 - 211