Ebola virus vaccination elicits Ebola virus-specific immune responses without substantial cross-reactivity to other filoviruses

被引：0

作者：

Mdluli, Thembi ^{[1
,2
]}

Wollen-Roberts, Suzanne ^{[1
,2
]}

Merbah, Melanie ^{[1
,2
]}

Beckman, Bradley ^{[1
,2
]}

Li, Yifan ^{[1
,2
]}

Alrubayyi, Aljawharah ^{[1
,2
]}

Curtis, Daniel J. ^{[1
,2
]}

Shubin, Zhanna ^{[1
,2
,15
]}

Barrera, Michael D. ^{[1
,2
]}

Boeckelman, Jacob ^{[1
,2
]}

Duncan, Shayla ^{[1
,2
]}

Thapa, Pallavi ^{[1
,2
]}

Kim, Dohoon ^{[1
,2
]}

Costanzo, Margaret C. ^{[1
,2
]}

Bai, Hongjun ^{[1
,2
]}

Dearlove, Bethany L. ^{[1
,2
]}

Hooper, Jay W. ^{[3
]}

Kwilas, Steven A. ^{[3
]}

Paquin-Proulx, Dominic ^{[1
,2
]}

Eller, Michael A. ^{[1
,2
,16
]}

Eller, Leigh Anne ^{[1
,2
]}

Kibuuka, Hannah ^{[4
]}

Mwesigwa, Betty ^{[4
]}

Kosgei, Josphat ^{[5
,6
]}

Sawe, Fredrick ^{[5
,6
]}

Oyieko, Janet ^{[5
,6
]}

Ntinginya, Nyanda ^{[7
]}

Mwakisisile, Joel ^{[7
]}

Jani, Ilesh ^{[8
]}

Viegas, Edna ^{[8
]}

Iroezindu, Michael ^{[1
,9
]}

Akintunde, Akindiran ^{[2
,9
,10
]}

Paolino, Kristopher ^{[11
,12
]}

Robb, Merlin L. ^{[1
,2
]}

Ward, Lucy ^{[13
]}

McLean, Chelsea ^{[14
]}

Luhn, Kerstin ^{[14
]}

Robinson, Cynthia ^{[14
]}

Ake, Julie A. ^{[1
]}

Rolland, Morgane ^{[1
,2
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA

[2] Henry M Jackson Fdn Advancement Mil Med Inc, Bethesda, MD 20817 USA

[3] US Army Med Res Inst Infect Dis USAMRIID, Ft Detrick, MD 21702 USA

[4] Makerere Univ, Walter Reed Project, Kampala, Uganda

[5] Henry M Jackson Fdn Med Res Int, Nairobi, Kenya

[6] Kenya Govt Med Res Ctr, US Army Med Res Directorate Africa, Kericho, Kenya

[7] Natl Inst Med Res, Mbeya Med Res Ctr, Mbeya, Tanzania

[8] Polana Can Hlth Res & Training Ctr, Maputo, Mozambique

[9] Henry M Jackson Fdn Med Res Int, Abuja, Nigeria

[10] US Army Med Res Directorate Africa, Abuja, Nigeria

[11] Walter Reed Army Inst Res, Clin Trials Ctr, Silver Spring, MD 20910 USA

[12] SUNY Upstate Med Univ, Inst Global Hlth & Translat Sci, Syracuse, NY 13210 USA

[13] US Dept Def DOD Joint Program Execut Off Chem, Joint Project Manager Chem, Biol, Ft Detrick, MD 21702 USA

[14] Janssen Vaccines & Prevent, Leiden, Netherlands

[15] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA

[16] Natl Inst Allergy & Infect Dis, Vaccine Res Program, Div AidS, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2025年 / 17卷 / 792期

关键词：

2-DOSE HETEROLOGOUS AD26.ZEBOV; PROTECTS NONHUMAN-PRIMATES; OPEN-LABEL; MEDIATED PROTECTION; MONOCLONAL-ANTIBODY; VACCINES; IMMUNOGENICITY; CHALLENGE; REGIMEN; SAFETY;

D O I：

10.1126/scitranslmed.adq2496

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Janssen Ebola virus (EBOV) vaccine consists of the adenovirus type 26 vector encoding the EBOV glycoprotein (GP) (Ad26.ZEBOV) and the modified vaccinia Ankara (MVA) vector encoding GP from EBOV, Sudan virus, and Marburg virus and nucleoprotein from Tai Forest virus (MVA-BN-Filo) administered 8 weeks later. We conducted a systems immunology analysis of antibody-mediated and cellular immune responses induced after two immunizations with either vaccine used first. The response to vaccination was EBOV GP specific and defined by high antibody binding, Fc effector, and neutralizing responses with CD4 T cell responses also contributing. The vaccine-induced antibody profile did not distinguish people living with or without HIV-1. Samples from 48 survivors and 121 contacts from the 2007 Ugandan Bundibugyo virus epidemic also showed minimal cross-reactivity to other filovirus proteins after infection and exposure. The lack of cross-reactivity suggests that different multivalent vaccine candidates are required to provide broad protection across filoviruses.

引用

页数：16

共 49 条

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