Tuberculosis after hematopoietic cell transplantation: retrospective study on behalf of the infectious diseases working party of the EBMT

被引：1

作者：

Drozd-Sokolowska, Joanna ^{[1
]}

Tridello, Gloria ^{[2
]}

Verheggen, Inge ^{[3
]}

Karakukcu, Musa ^{[4
]}

Ben Abdeljelil, Nour ^{[5
]}

Colita, Anca ^{[6
]}

Aljurf, Mahmoud ^{[7
]}

Kroeger, Nicolaus ^{[8
]}

Ozturk, Gulyuz ^{[9
]}

Passweg, Jakob ^{[10
]}

Gambella, Massimiliano ^{[11
]}

Popova, Marina ^{[12
]}

Lopez Corral, Lucia ^{[13
]}

Tanase, Alina ^{[6
]}

Piekarska, Agnieszka ^{[14
]}

Al Zahrani, Mohsen ^{[15
]}

Ar, Muhlis Cem ^{[16
]}

Basak, Grzegorz ^{[1
]}

Broers, Annoek E. C. ^{[17
]}

Carlson, Kristina ^{[18
]}

Clark, Andrew ^{[19
]}

Faraci, Maura ^{[20
]}

Jindra, Pavel ^{[21
]}

Krivan, Gergely ^{[22
]}

Ducastelle Lepretre, Sophie ^{[23
]}

Mielke, Stephan ^{[24
]}

Niederland, Judith ^{[25
]}

Pane, Fabrizio ^{[26
]}

Patrick, Katharine ^{[27
]}

Snowden, John A. ^{[28
]}

Yavasoglu, Irfan ^{[29
]}

Zecca, Marco ^{[30
]}

Waszczuk-Gajda, Anna ^{[1
]}

Wendel, Lotus ^{[3
]}

Knelange, Nina ^{[3
]}

de la Camara, Rafael ^{[31
]}

Gil, Lidia ^{[32
]}

Mikulska, Malgorzata ^{[11
,33
]}

Averbuch, Dina ^{[34
]}

Styczynski, Jan ^{[35
]}

机构：

[1] Med Univ Warsaw, Cent Clin Hosp, Warsaw, Poland

[2] EBMT Leiden, Stat Unit, Leiden, Netherlands

[3] EBMT Leiden, Study Unit, Leiden, Netherlands

[4] Erciyes Univ, Fac Med, Kayseri, Turkiye

[5] Ctr Natl Greffe de Moelle, Tunis, Tunisia

[6] Fundeni Clin Inst, Bucharest, Romania

[7] King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia

[8] Univ Hosp Eppendorf, Hamburg, Germany

[9] Aibadem Saglik Hizm & Tic AS, Istanbul, Turkiye

[10] Univ Hosp Basel, Basel, Switzerland

[11] IRCCS Osped Policlin San Martino, Genoa, Italy

[12] Pavlov Univ, RM Gorbacheva Res Inst, St Petersburg, Russia

[13] Hosp Clin Salamanca, Salamanca, Spain

[14] Univ Clin Ctr Gdansk, Gdansk, Poland

[15] King Abdul Aziz Med City, Riyadh, Saudi Arabia

[16] Istanbul Univ Cerrahpasa, Istanbul, Turkiye

[17] Erasmus MC Canc Inst, Rotterdam, Netherlands

[18] Univ Hosp Uppsala, Uppsala, Sweden

[19] Glasgow Royal Infirm, Glasgow, Scotland

[20] IRCCS Inst G Gaslini, Genoa, Italy

[21] Charles Univ Hosp, Plzen, Czech Republic

[22] Cent Hosp Southern Pest, Budapest, Hungary

[23] Ctr Hosp Lyon sud, Lyon, France

[24] Karolinska Univ Hosp, Stockholm, Sweden

[25] HELIOS Klinikum Berlin Buch, Berlin, Germany

[26] Univ Napoli, Naples, Italy

[27] Sheffield Childrens NHS Fdn Trust, Sheffield, England

[28] Sheffield Teaching Hosp NHS Fdn Trust, Dept Haematol, Sheffield, England

[29] Adnan Menderes Univ, Med Fac, Aydin, Turkiye

[30] San Matteo Pavia Transplant Programme, Pavia, Italy

[31] Hosp La Princesa, Madrid, Spain

[32] Poznan Univ Med Sci, Dept Hematol, Poznan, Poland

[33] Univ Genoa DISSAL, Genoa, Italy

[34] Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Pediat Infect Dis, Jerusalem, Israel

[35] Coll Medicum UMK Toruniu, Coll Med UMK, Bydgoszcz, Poland

来源：

BONE MARROW TRANSPLANTATION | 2025年 / 60卷 / 05期

关键词：

IMMUNE RECONSTITUTION SYNDROME; BONE-MARROW-TRANSPLANTATION; MYCOBACTERIAL INFECTION; PULMONARY TUBERCULOSIS; ACTIVE TUBERCULOSIS; RISK-FACTORS; RECIPIENTS;

D O I：

10.1038/s41409-025-02530-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Tuberculosis (TB) is rare following hematopoietic cell transplantation (HCT). In this multinational retrospective study, we report the frequency, characteristics, and outcome of TB following HCT performed during 2000-2019. Fifty-two patients (35 (67%) males, 15 (29%) children) from 24 centers developed TB following allogeneic (n = 47) or autologous (n = 5) HCT; with the relative frequency of 0.21% and 0.025%, respectively. Forty (77%) were bacteriologically, 12 (23%) clinically confirmed. The median time from HCT to TB was 135 (range, 16-3225) days. Eighteen (35%) patients with extrapulmonary TB (mainly involving lymph nodes and liver/spleen) were significantly younger, developed TB shorter after HCT, more often had inherited underlying disease, and received immunosuppressive therapy at TB diagnosis as compared to pulmonary TB. Five (22%) of 23 patients with drug-susceptibility testing performed, were resistant to at least one anti-TB drug. Treatment success was achieved in 38/50 (76%) of treated patients. One-year overall survival reached 75.7% and the 1-year cumulative incidence of TB-associated death was 18.1%. Concluding, TB is a rare, albeit severe complication, which can develop any time after HCT, frequently involves extrapulmonary sites, and results in high mortality rates. High proportion of drug-resistant TB warrants routine susceptibility testing.

引用

页码：603 / 616

页数：14

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