Locking the Fate: How PROX1 Represses Plasticity and Liver Cancer

被引：0
作者：
Lee, Seung-Won [1 ]
Kim, Jungsun [1 ,2 ,3 ]
机构：
[1] Oregon Hlth & Sci Univ OHSU, Knight Canc Inst, Canc Early Detect Adv Res Ctr, Sch Med, Portland, OR 97239 USA
[2] OHSU, Sch Med, Dept Mol & Med Genet, Portland, OR USA
[3] OHSU, Knight Canc Inst, Canc Biol Program, Sch Med, Portland, OR USA
来源：
CELLULAR REPROGRAMMING | 2025年
关键词：
prospero homeobox protein 1 (PROX1); hepatocytic safeguard repressor cell identity; plasticity;
D O I：
10.1089/cell.2025.0013
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
A Transcriptional Ridge in the Waddington Landscape. The Waddington landscape model, proposed in 1957, provides a powerful framework for understanding cell fate determination (Waddington, 1957). As development progresses, cells become restricted to distinct fates, separated by high "ridges" that prevent identity switching. A recent study in Nature Genetics uncovers such a ridge in hepatocyte lineage specification (Lim et al., 2025). Lim et al. report that prospero homeobox protein 1 (PROX1) acts as a hepatocyte-specific safeguard repressor, ensuring lineage stability by actively suppressing alternative cell fates and preventing cholangiocarcinoma development.
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