Caspase-8: Arbitrating Life and Death in the Innate Immune System

被引：0
作者：
Gupta, Sahil [1 ,2 ,3 ]
Lopez, Monica Aida [2 ]
Ektesabi, Amin M. [2 ,3 ]
Tsoporis, James N. [2 ]
Vaswani, Chirag M. [2 ,4 ]
Gandhi, Shil Y. [1 ]
Fairn, Gregory D. [2 ,5 ]
Dos Santos, Claudia C. [2 ,3 ,4 ]
Marshall, John C. [2 ,3 ,6 ]
机构：
[1] Univ Queensland, Fac Med, Med Sch, Brisbane, Qld 4006, Australia
[2] St Michaels Hosp, Unity Hlth Toronto, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1W8, Canada
[3] Univ Toronto, Inst Med Sci, Temerty Fac Med, Toronto, ON M5S 3K3, Canada
[4] Univ Toronto, Temerty Fac Med, Dept Physiol, Toronto, ON M5S 3K3, Canada
[5] Dalhousie Univ, Dept Pathol, Halifax, NS B3H 4R2, Canada
[6] St Michaels Hosp, Unity Hlth Toronto, Dept Crit Care Med, Toronto, ON M5B 1W8, Canada
来源：
CELLS | 2025年 / 14卷 / 04期
关键词：
caspase-8; apoptosis; inflammation; alternative splicing; post-translational modification; PROGRAMMED CELL-DEATH; NEUTROPHIL SURVIVAL; SRC KINASE; APOPTOSIS; PHOSPHORYLATION; ACTIVATION; EFFECTOR; POLYUBIQUITINATION; DEPHOSPHORYLATION; UBIQUITINATION;
D O I：
10.3390/cells14040240
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The canonical function of caspase-8 is to control timely cellular apoptosis to maintain tissue homeostasis and clear dysfunctional cells; however, emerging findings reveal novel, non-canonical roles of caspase in addition to regulating cellular apoptosis, including inflammatory response regulation, immune function, and cell differentiation. Furthermore, the functional versatility of caspase-8 is reported to be contingent on the presence and dimerization of various isoforms, which are produced through alternative splicing, altering its function and protein-protein interactions. Equally important are post-translational modifications, including phosphorylation and ubiquitination, which can act as a nexus to control caspase-8 activity and cellular localization. Here, we review the alternative splicing and post-translational modifications made to caspase-8 and discuss their influence on its canonical and non-canonical roles.
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页数：13
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