Prognostic Significance of Tumor Budding in Ampullary Carcinomas

被引：0

作者：

Akar, Kadriye Ebru ^{[1
]}

Bagci, Pelin ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Dept Pathol, Fevzi Cakmak Muhsin Yazicioglu St 10, TR-34899 Pendik, Istanbul, Turkiye

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2025年 / 33卷 / 05期

关键词：

ampulla of Vater; carcinoma; adenocarcinoma; pancreas; tumor budding; VATER; CANCER; PANCREATICODUODENECTOMY; CLASSIFICATION; PREDICTORS; RECURRENCE; RESECTION; PAPILLA;

D O I：

10.1177/10668969241308204

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective. The presence of high tumor budding in colorectal carcinomas is a significant pathological feature indicative of a high potential for lymph node metastasis. Our aim was to investigate the prognostic impact of tumor budding in ampullary carcinomas. Materials and methods. We conducted a cohort of 101 consecutive ampullary carcinoma resections to evaluate tumor budding, macroscopic and microscopic subtypes, lymphatic/vascular/perineural invasions, and other histopathological parameters. Results. High tumor budding was observed in 49 (49%) of the tumors, and multivariate survival analysis evaluating the overall survival of these patients found tumor budding to be an independent poor prognostic indicator (p = 0.013). Conclusion. Tumor budding should be reported in ampullary carcinomas as it serves as an independent predictor of a poor outcome.

引用

页码：1135 / 1141

页数：7

共 30 条

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