Effect of e-cigarettes for smoking cessation on depressive and anxiety symptoms: Secondary analysis of a randomized controlled trial

被引:2
作者
Rihs, Anna [1 ,2 ]
Schoeni, Anna [1 ]
Scharf, Tamara [1 ,3 ]
Jakob, Julian [1 ,3 ,4 ]
Tal, Kali [1 ]
Jacot-Sadowski, Isabelle [5 ]
Humair, Jean-Paul [6 ]
Frei, Anja [7 ]
Brutsche, Martin [8 ]
Rodondi, Nicolas [1 ,2 ]
Auer, Reto [1 ,5 ]
Baggio, Stephanie [1 ,9 ]
机构
[1] Univ Bern, Inst Primary Hlth Care BIHAM, Mittelstr 43, CH-3012 Bern, Switzerland
[2] Univ Bern, Bern Univ Hosp, Inselspital, Dept Gen Internal Med, Bern, Switzerland
[3] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland
[4] Univ Bern, Bern Univ Hosp, Inselspital, Dept Paediat, Bern, Switzerland
[5] Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland
[6] Univ Hosp Geneva, Dept Primary Care Med, Geneva, Switzerland
[7] Univ Zurich, Epidemiol Biostat & Prevent Inst, Zurich, Switzerland
[8] Kantonsspital St Gallen, Lung Ctr, St Gallen, Switzerland
[9] Univ Fribourg, Lab Populat Hlth PopHealthLab, Fribourg, Switzerland
基金
瑞士国家科学基金会;
关键词
E; -cigarettes; Electronic nicotine delivery systems (ENDS); Depression; Anxiety; Mental health symptoms; SMOKERS; ASSOCIATION; ABSTINENCE; PHQ-9; DEPENDENCE; SEVERITY; TOBACCO;
D O I
10.1016/j.genhosppsych.2025.01.011
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: This study aims to assess differences in depressive and anxiety symptoms at 6-month follow-up in a smoking cessation trial using e-cigarettes as quitting aids. Methods: We conducted a secondary analysis of the Swiss multicentre ESTxENDS smoking cessation randomized controlled trial (RCT) assessing differences in depressive (Patient Health Questionnaire-9, PHQ-9, range: 0-27) and anxiety symptoms (General Anxiety Disorder-7, GAD-7, range: 0-21) at 6-month follow-up comparing participants who received e-cigarettes to those who received smoking cessation counseling alone. Results: Of 1244 participants 913 completed the PHQ-9 and 884 the GAD-7 at 6-month follow-up. Mean PHQ-9 scores (SD) at 6 months for the intervention group were 3.7 (3.9), control group: 4.0 (4.2); mean GAD-7 scores (SD) at 6 months for the intervention group were 4.6 (4.3), control group: 4.6 (4.4). Multivariable analyses showed no evidence of a clinically relevant intervention effect on the PHQ-9 [coefficient- 0.101, 95 % CI-0.182 to-0.019, p = .016, corresponding to a 0.9 decrease of the original PHQ-9 score] and the GAD-7 scores [coefficient- 0.056, 95 % CI-0.135 to 0.022, p = .160] in the main adjusted models. Conclusions: Among smokers who participated in the ESTxENDS smoking cessation trial, we found distribution of e-cigarettes for smoking cessation in addition to standard counseling compared to counseling alone had no clinically relevant effect on depressive or anxiety symptoms at 6-month follow-up. Trial Registration: ClinicalTrials NCT03603340
引用
收藏
页码:67 / 72
页数:6
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