Effect of e-cigarettes for smoking cessation on depressive and anxiety symptoms: Secondary analysis of a randomized controlled trial

被引：2

作者：

Rihs, Anna ^{[1
,2
]}

Schoeni, Anna ^{[1
]}

Scharf, Tamara ^{[1
,3
]}

Jakob, Julian ^{[1
,3
,4
]}

Tal, Kali ^{[1
]}

Jacot-Sadowski, Isabelle ^{[5
]}

Humair, Jean-Paul ^{[6
]}

Frei, Anja ^{[7
]}

Brutsche, Martin ^{[8
]}

Rodondi, Nicolas ^{[1
,2
]}

Auer, Reto ^{[1
,5
]}

Baggio, Stephanie ^{[1
,9
]}

机构：

[1] Univ Bern, Inst Primary Hlth Care BIHAM, Mittelstr 43, CH-3012 Bern, Switzerland

[2] Univ Bern, Bern Univ Hosp, Inselspital, Dept Gen Internal Med, Bern, Switzerland

[3] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland

[4] Univ Bern, Bern Univ Hosp, Inselspital, Dept Paediat, Bern, Switzerland

[5] Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland

[6] Univ Hosp Geneva, Dept Primary Care Med, Geneva, Switzerland

[7] Univ Zurich, Epidemiol Biostat & Prevent Inst, Zurich, Switzerland

[8] Kantonsspital St Gallen, Lung Ctr, St Gallen, Switzerland

[9] Univ Fribourg, Lab Populat Hlth PopHealthLab, Fribourg, Switzerland

来源：

GENERAL HOSPITAL PSYCHIATRY | 2025年 / 93卷

基金：

瑞士国家科学基金会;

关键词：

E; -cigarettes; Electronic nicotine delivery systems (ENDS); Depression; Anxiety; Mental health symptoms; SMOKERS; ASSOCIATION; ABSTINENCE; PHQ-9; DEPENDENCE; SEVERITY; TOBACCO;

D O I：

10.1016/j.genhosppsych.2025.01.011

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: This study aims to assess differences in depressive and anxiety symptoms at 6-month follow-up in a smoking cessation trial using e-cigarettes as quitting aids. Methods: We conducted a secondary analysis of the Swiss multicentre ESTxENDS smoking cessation randomized controlled trial (RCT) assessing differences in depressive (Patient Health Questionnaire-9, PHQ-9, range: 0-27) and anxiety symptoms (General Anxiety Disorder-7, GAD-7, range: 0-21) at 6-month follow-up comparing participants who received e-cigarettes to those who received smoking cessation counseling alone. Results: Of 1244 participants 913 completed the PHQ-9 and 884 the GAD-7 at 6-month follow-up. Mean PHQ-9 scores (SD) at 6 months for the intervention group were 3.7 (3.9), control group: 4.0 (4.2); mean GAD-7 scores (SD) at 6 months for the intervention group were 4.6 (4.3), control group: 4.6 (4.4). Multivariable analyses showed no evidence of a clinically relevant intervention effect on the PHQ-9 [coefficient- 0.101, 95 % CI-0.182 to-0.019, p = .016, corresponding to a 0.9 decrease of the original PHQ-9 score] and the GAD-7 scores [coefficient- 0.056, 95 % CI-0.135 to 0.022, p = .160] in the main adjusted models. Conclusions: Among smokers who participated in the ESTxENDS smoking cessation trial, we found distribution of e-cigarettes for smoking cessation in addition to standard counseling compared to counseling alone had no clinically relevant effect on depressive or anxiety symptoms at 6-month follow-up. Trial Registration: ClinicalTrials NCT03603340

引用

页码：67 / 72

页数：6

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