Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials?

被引：3
作者：
Domaszewska-Szostek, Anna [1 ]
Krzyzanowska, Marta [2 ]
Polak, Agnieszka [3 ]
Puzianowska-Kuznicka, Monika [1 ,4 ]
机构：
[1] Polish Acad Sci, Mossakowski Med Res Inst, Dept Human Epigenet, PL-02106 Warsaw, Poland
[2] Nicolaus Copernicus Univ, Dept Ophthalmol, Coll Medicum, PL-85094 Bydgoszcz, Poland
[3] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Hills Rd, Cambridge CB2 0SP, England
[4] Med Ctr Postgrad Educ, Dept Geriatr & Gerontol, PL-01826 Warsaw, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 05期
关键词：
extracellular vesicles; exosomes; skin aging; clinical trials; regenerative medicine; EXOSOMES; REJUVENATION; MECHANISMS;
D O I：
10.3390/ijms26052354
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent years, there has been a dynamic development in therapies utilizing extracellular vesicles (EVs) including exosomes. Therefore, we have conducted an analysis of the scientific literature to verify the current state of knowledge about these therapies. A total of 12 clinical studies were analyzed, covering the use of EVs in treating skin aging, acne scars, alopecia, and wound healing. The results indicate that EVs and exosomes hold potential in regenerative skin therapies, offering innovative and non-invasive therapeutic approaches. At the same time, significant challenges related to the standardization of their production and the lack of large-scale randomized studies were identified. Thus, we also evaluated the investigated clinical trials in regard to the MISEV (Minimal Information for Studies of Extracellular Vesicles) criteria. This review provides a comprehensive overview of the contemporary applications of EVs in skin therapy and regenerative medicine, highlighting directions for further research.
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页数：23
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