Pathways from Adverse Childhood Family Environment to Lower Urinary Tract Symptoms and Impact Among Women

被引:0
作者
Brady, Sonya S. [1 ]
Arguedas, Andres [2 ]
Huling, Jared D. [2 ]
Hellemann, Gerhard [3 ]
Jacobs, David R. [4 ]
Lewis, Cora E. [5 ]
Fok, Cynthia S. [6 ]
van den Eeden, Stephen K. [7 ,8 ]
Markland, Alayne D. [9 ,10 ]
机构
[1] Univ Minnesota, Dept Family Med & Community Hlth, Program Hlth Dispar Res, Med Sch, 717 Delaware St SE,Suite 166, Minneapolis, MN 55414 USA
[2] Univ Minnesota, Div Biostat, Sch Publ Hlth, Minneapolis, MN USA
[3] Univ Alabama Birmingham, Dept Biostat, Sch Publ Hlth, Birmingham, AL USA
[4] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN USA
[5] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA
[6] Univ Minnesota, Dept Urol, Med Sch, Minneapolis, MN USA
[7] Kaiser Permanente Northern Calif, Div Res, Pleasanton, CA USA
[8] Univ Calif San Francisco, Dept Urol, San Francisco, CA USA
[9] Univ Alabama Birmingham, Div Gerontol Geriatr & Palliat Care, Sch Med, Birmingham, AL USA
[10] Birmingham VA Med Ctr, Birmingham, AL USA
关键词
adverse childhood experiences; lower urinary tract symptoms; bladder health; quality of life; mediation; women; ARTERY RISK DEVELOPMENT; QUALITY-OF-LIFE; OVERACTIVE BLADDER; CARDIOVASCULAR HEALTH; INCONTINENCE; STRESS; ADULTS; INDEX; EXPERIENCES; DEPRESSION;
D O I
10.1089/jwh.2024.0790
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: To advance existing knowledge, this study examined mechanisms that may link retrospectively reported adverse childhood family environment (ACFE) to lower urinary tract symptoms and their impact (LUTS/impact), a composite variable with four levels (bladder health and mild, moderate, or severe LUTS/impact), among women (n = 1,026) in the Coronary Artery Risk Development in Young Adults cohort study. A prior study demonstrated that ACFE was associated with greater LUTS/impact.Materials and Methods: In 2000-01, the frequency of ACFE events was retrospectively assessed. In 2012-13, data on LUTS/impact were collected. Between 1985-86 and 2010-11, data on proposed mediators were collected at varying time points and averaged to form composite variables. A series of proportional odds ordinal logistic regression analyses were conducted. LUTS/impact was regressed on ACFE, adjusting for age, race, education, and parity. A single proposed mediator was added to the model at one time to determine whether the strength of the association between ACFE and LUTS/impact was attenuated.Results: When entered into regression models individually, life stressors, low levels of emotional support, and depressive symptoms each significantly attenuated the association between ACFE and LUTS/impact, with the association becoming nonsignificant when depressive symptoms were entered. Remaining proposed mediators (social network extensiveness, health behaviors, physiological health, cognitive function) did not mediate the association.Conclusions: ACFE may place women at risk for repeated or chronic episodes of experiencing life stressors, low support, and depressive symptoms during early and midlife adulthood, which in turn may place women at risk for more LUTS and impact during midlife adulthood.
引用
收藏
页码:549 / 561
页数:13
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