Beyond Pallidal or Subthalamic Deep Brain Stimulation to Treat Dystonia

被引：0
作者：
Garg, Vedant [1 ]
Srikar, Venkat [1 ]
Hey, Grace [1 ]
Winter, Brett [1 ]
Firme, Marcos Santana [1 ]
Hilliard, Justin D. [2 ]
De Hemptinne, Coralie [1 ]
Okun, Michael S. [1 ]
Wong, Joshua K. [1 ]
机构：
[1] Univ Florida, Norman Fixel Inst Neurol Dis, Dept Neurol, 3009 SW Williston Rd, Gainesville, FL 32608 USA
[2] Univ Florida, Norman Fixel Inst Neurol Dis, Dept Neurosurg, Gainesville, FL 32608 USA
来源：
TREMOR AND OTHER HYPERKINETIC MOVEMENTS | 2024年 / 14卷
关键词：
dystonia; neuromodulation; deep brain stimulation; thalamus; cerebellum; TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; GENERALIZED DYSTONIA; GLOBUS-PALLIDUS; MOTOR CORTEX; MOVEMENT; SYMPTOMS;
D O I：
10.5334/tohm.935
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Deep brain stimulation of the subthalamic nucleus and globus pallidus internus is approved by the Food and Drug Administration for treating dystonia. Both targets have shown effectiveness in improving symptoms, but post-operative outcomes can vary significantly among patients. This variability has led researchers to explore alternative neuromodulation targets that might offer more consistent results. Emerging research has highlighted several promising new targets for DBS in dystonia. This review examines pre-clinical and clinical data on novel DBS targets for dystonia and explores non-invasive neuromodulation studies that shed light on the disease's underlying pathological circuitry.
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页数：12
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