Mn(I)-Catalyzed C-H Allylation of Indoles with 2-Vinylaziridines

被引：0
|
作者：
Zeng, Hong [1 ,2 ]
Wang, Zhong-Xia [1 ,2 ]
机构：
[1] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Manganese catalysis; Indoles; Vinylaziridines; C-H activation; Allylation; ALCOHOLS;
D O I：
10.1002/ajoc.202400467
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Mn(CO)5Br-catalyzed reaction of 1-(2-pyrimidyl)indoles with 1-sulfonyl-2-vinylaziridines in THF in the presence of 0.25 equiv. of NaOAc affords 2-allylated indoles in 31 % to 100 % yields. The protocol suits for 3-, 4-, 5-, 6-, and 7-substituted indoles and N-(2-pyrimidyl)pyrroles as well as various 1-(arylsulfonyl)-2-vinylaziridines such as 1-(phenylsulfonyl)-2-vinylaziridine, 1-(naphthalen-2-ylsulfon-yl)-2-vinylaziridine, and 1-(substituted phenylsulfonyl)-2-vinylazirid-ines. Functional groups including alkyl, alkoxy, halogen, CHO, COOMe, CF3, CN, and NO2 groups are tolerated.
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页数：5
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