Ginger-derived nanovesicles attenuate osteoarthritis progression by inhibiting oxidative stress via the Nrf2 pathway

被引：1
作者：
Zeng, Yiming [1 ]
Yu, Shun [2 ]
Lu, Lin [3 ]
Zhang, Jun [1 ]
Xu, Chen [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Orthoped, Shanghai Key Lab Orthoped Implants,Sch Med, Shanghai 200011, Peoples R China
[2] Jiangnan Univ, Affiliated Hosp, Dept Burns & Plast Surg, Wuxi 214041, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R China
来源：
NANOMEDICINE | 2024年 / 19卷 / 28期
关键词：
ginger-derived nanovesicles; inflammation; Nrf2; osteoarthritis; oxidative stress; PLANT; NANOPARTICLES; CELLS; KNEE;
D O I：
10.1080/17435889.2024.2403324
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: Osteoarthritis (OA) is a common degenerative joint disease. Previous studies demonstrated ginger-derived exosome-like nanovesicles (GDN) showed therapeutic effects in degenerative diseases. However, it remains unknown whether GDN could alleviate OA progression. Materials & methods: In this study, GDN were obtained and characterized. Then we evaluated the effects of GDN in tert-butyl hydroperoxide (TBHP)-induced chondrocytes, posttraumatic OA rat model and ex vivo cultured human OA cartilage explants. Results: We demonstrated GDN promoted cartilage anabolism and alleviated oxidative stress in TBHP-induced chondrocytes and OA rat. Our results also showed GDN exhibited protective effects in cultured cartilage explants. Furthermore, we verified the Nrf2 pathway was associated with protective effects of GDN. Conclusion: Altogether, our findings demonstrated GDN hold great potential for OA treatment.
引用
收藏
页码：2357 / 2373
页数：17
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