Genetics of Female Pelvic Organ Prolapse: Up to Date

被引：5

作者：

Li, Yuting ^{[1
,2
]}

Li, Zihan ^{[1
,2
]}

Li, Yinuo ^{[1
,2
]}

Gao, Xiaofan ^{[1
,2
]}

Wang, Tian ^{[1
,2
]}

Huang, Yibao ^{[1
,2
]}

Wu, Mingfu ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Natl Clin Res Ctr Obstetr & Gynecol Dis, Dept Gynecol,Tongji Hosp, Wuhan 430030, Peoples R China

[2] Minist Educ, Key Lab Canc Invas & Metastasis, Wuhan 430030, Peoples R China

来源：

BIOMOLECULES | 2024年 / 14卷 / 09期

关键词：

pelvic organ prolapse; extracellular matrix; genetics; single-nucleotide polymorphisms; genome-wide association studies; epigenetic; LEVATOR ANI MUSCLE; UTEROSACRAL LIGAMENT FIBROBLASTS; SP1-BINDING SITE POLYMORPHISM; STRESS URINARY-INCONTINENCE; ELASTIC FIBER HOMEOSTASIS; ESTROGEN-RECEPTOR; ALPHA-1; POLYMORPHISM; RISK-FACTORS; WOMEN; EXPRESSION;

D O I：

10.3390/biom14091097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pelvic organ prolapse (POP) is a benign disease characterized by the descent of pelvic organs due to weakened pelvic floor muscles and fascial tissues. Primarily affecting elderly women, POP can lead to various urinary and gastrointestinal tract symptoms, significantly impacting their quality of life. The pathogenesis of POP predominantly involves nerve-muscle damage and disorders in the extracellular matrix metabolism within the pelvic floor. Recent studies have indicated that genetic factors may play a crucial role in this condition. Focusing on linkage analyses, single-nucleotide polymorphisms, genome-wide association studies, and whole exome sequencing studies, this review consolidates current research on the genetic predisposition to POP. Advances in epigenetics are also summarized and highlighted, aiming to provide theoretical recommendations for risk assessments, diagnoses, and the personalized treatment for patients with POP.

引用

页数：17

共 103 条

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