Novel strategies in topical delivery for psoriasis treatment: nanocarriers and energy-driven approaches

被引：0

作者：

Lin, Cheng-Yu ^{[1
]}

Lin, Zih-Chan ^{[2
]}

Chang, Yen-Tzu ^{[3
]}

Lin, Tsai-Jie ^{[4
]}

Fang, Jia-You ^{[5
,6
,7
,8
]}

机构：

[1] Duke Univ, Sch Med, Dept Pathol, Durham, NC USA

[2] Chang Gung Univ Sci & Technol, Chron Dis & Hlth Promot Res Ctr, Chiayi, Taiwan

[3] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX USA

[4] Natl Chiayi Univ, Dept Food Sci, Chiayi, Taiwan

[5] Chang Gung Univ, Grad Inst Nat Prod, Pharmaceut Lab, 259 Wen Hwa 1st Rd, Taoyuan 333, Taiwan

[6] Chang Gung Univ Sci & Technol, Res Ctr Food & Cosmet Safety, Taoyuan, Taiwan

[7] Chang Gung Univ Sci & Technol, Ctr Drug Res & Dev, Taoyuan, Taiwan

[8] Chang Gung Mem Hosp, Dept Anesthesiol, Linkou, Taiwan

来源：

EXPERT OPINION ON DRUG DELIVERY | 2025年

关键词：

Psoriasis; skin; nanocarrier; RNA therapy; microneedle; TRANSDERMAL DRUG-DELIVERY; ARYL-HYDROCARBON RECEPTOR; PLAQUE PSORIASIS; LIPID NANOPARTICLES; SYSTEM; SKIN; FORMULATION; CARRIERS; CREAM; METHOTREXATE;

D O I：

10.1080/17425247.2025.2472968

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

IntroductionPsoriasis is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. This condition presents significant challenges for effective drug delivery. In addition to overcoming the thickness of the skin, topical treatments must navigate the complex hydrophobic and hydrophilic properties of the skin barrier. Recent advancements in nanocarrier technologies, including energy-driven methods and microneedles that penetrate the stratum corneum, present promising strategies for enhancing drug permeation through tailored physicochemical properties. A literature search was performed using the databases of Google Scholar, PubMed, and ScienceDirect.Areas coveredThis review highlights recent studies on novel topical delivery methods for psoriasis treatment, addressing current therapeutic options and their limitations. We provide a comprehensive overview of chemical nanoformulations and explore physical strategies to improve delivery rates. Furthermore, we discuss the advantages of various formulations that can carry different types of payloads, offering patients diverse strategies for symptom management. The review covers conventional treatments, emphasizing advancements in nanoparticle design and novel macromolecular drugs. This includes Ribonucleic acid (RNA)-based therapies that protect macromolecular drugs from rapid clearance in the body.Expert opinionWe argue that intelligent design approaches can enhance efficacy across delivery applications while allowing for precision in treatment strategies, ultimately improving patient outcomes.

引用

页码：565 / 581

页数：17

共 105 条

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