Role of Epigenetics in Chronic Lung Disease

被引：1

作者：

Ritzmann, Felix ^{[1
]}

Brand, Michelle ^{[1
,2
]}

Bals, Robert ^{[1
,2
]}

Wegmann, Michael ^{[3
,4
]}

Beisswenger, Christoph ^{[1
]}

机构：

[1] Saarland Univ, Dept Internal Med V Pulmonol Allergol & Resp Crit, D-66421 Homburg, Germany

[2] Helmholtz Inst Pharmaceut Res, D-66123 Saarbrucken, Germany

[3] Leibniz Lung Ctr, Res Ctr Borstel, Div Lung Immunol, Prior Area Asthma & Allergy, D-23845 Borstel, Germany

[4] German Ctr Lung Res DZL, Airway Res Ctr North ARCN, D-23845 Borstel, Germany

来源：

CELLS | 2025年 / 14卷 / 04期

关键词：

epigenetics; lung disease; trained immunity; OBSTRUCTIVE PULMONARY-DISEASE; GENOME-WIDE METHYLATION; DNA METHYLATION; CHILDHOOD ASTHMA; SMOKING; DIFFERENTIATION; INFECTIONS; EXPRESSION; MANAGEMENT; SIGNATURES;

D O I：

10.3390/cells14040251

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetics regulates gene expression and thus cellular processes that underlie the pathogenesis of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Environmental factors (e.g., air pollution, smoking, infections, poverty), but also conditions such as gastroesophageal reflux, induce epigenetic changes long before lung disease is diagnosed. Therefore, epigenetic signatures have the potential to serve as biomarkers that can be used to identify younger patients who are at risk for premature loss of lung function or diseases such as IPF. Epigenetic analyses also contribute to a better understanding of chronic lung disease. This can be used directly to improve therapies, as well as for the development of innovative drugs. Here, we highlight the role of epigenetics in the development and progression of chronic lung disease, with a focus on DNA methylation.

引用

页数：16

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