Impact of metabolic and weight components on incident asthma using a real-world cohort

被引:0
作者
Bloodworth, Melissa H. [1 ]
Staso, Patrick J. [1 ]
Huang, Shi [2 ]
Farber-Eger, Eric [1 ]
Niswender, Kevin D. [1 ]
Harrell, Frank E. [2 ]
Wells, Quinn S. [3 ]
Bacharier, Leonard B. [1 ,4 ]
Shuey, Megan M. [1 ]
Cahill, Katherine N. [1 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37203 USA
[2] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37203 USA
[3] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN 37203 USA
[4] Monroe Carell Jr Childrens Hosp Vanderbilt, Dept Pediat, Nashville, TN USA
关键词
BODY-MASS INDEX; ATRIAL-FIBRILLATION; OBESITY; ASSOCIATION; DYSREGULATION; INFLAMMATION; DIAGNOSIS; BURDEN; ADULTS;
D O I
10.1016/j.anai.2024.09.005
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Obesity and metabolic dysregulation (MetD) have increasing prevalence and adversely affect asthma morbidity and therapeutic response. Objective: To determine the role of weight and MetD on incident asthma in adulthood. Methods: In a retrospective, longitudinal cohort of patients, we performed a time-to-asthma diagnosis analysis after a 3-year landmark period (t(0)-t(3)) during which weight and MetD components were evaluated. We assessed incident asthma risk with MetD components and weight. Results: In total, 90,081 patients met the inclusion criteria, with 836 cases (0.93%) of incident asthma in our primary cohort. Diabetes present at t(0), but no other MetD components, was associated with increased risk of asthma (adjusted hazard ratio = 1.85, 95% CI: 1.27-2.71, P = .0002). The effect of weight on asthma risk, independent of other MetD components, identified individuals with overweight or obesity as having a 10-year attributable risk of 15.4%. Metformin was prescribed more frequently, and hemoglobin A1c levels were lower in patients with diabetes in whom asthma did not develop (P < .0001). Conclusion: Weight and diabetes prevention and management represent modifiable risk factors for adult asthma development. (c) 2024 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
引用
收藏
页码:660 / 666.e5
页数:12
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