Towards personalized vaccines

被引：1

作者：

Montin, Davide ^{[1
]}

Santilli, Veronica ^{[2
]}

Beni, Alessandra ^{[3
]}

Costagliola, Giorgio ^{[4
]}

Martire, Baldassarre ^{[5
]}

Mastrototaro, Maria Felicia ^{[5
]}

Ottaviano, Giorgio ^{[6
]}

Rizzo, Caterina ^{[7
]}

Sgrulletti, Mayla ^{[8
,9
]}

Giudice, Michele Miraglia Del ^{[10
]}

Moschese, Viviana ^{[8
]}

机构：

[1] Regina Margher Children Hosp, Div Pediat Immunol & Rheumatol, Turin, Italy

[2] IRCCS Bambino Gesu Childrens Hosp, Acad Dept Pediat DPUO, Res Unit Clin Immunol & Vaccinol, Rome, Italy

[3] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[4] Azienda Osped Univ Pisana, Sect Pediat Hematol & Oncol, I-56126 Pisa, Italy

[5] Monsignor AR Dimiccoli Hosp, Un Operativa Complessa UOC Pediat & Neonatol, Barletta, Italy

[6] Fdn IRCCS San Gerardo Tintori, Dept Pediat, Monza, Italy

[7] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy

[8] Univ Roma Tor Vergata, Pediat Immunopathol & Allergol Unit, Policlin Tor Verg ata, Rome, Italy

[9] Univ Roma Tor Vergata, PhD Program Immunol Mol Med & Appl Biotechnol, Rome, Italy

[10] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Naples, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

vaccines; vaccinomics and personalized vaccines; system vaccinology; proteomics; genomics; transcriptomics; precision medicine; INDUCED IMMUNE-RESPONSES; MEASLES-VACCINE; POLYMORPHISMS; OBESITY; CD46; SNPS; SLAM;

D O I：

10.3389/fimmu.2024.1436108

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored to individual genetic and immunological profiles. Integrating insights from genomics, transcriptomics, proteomics, and immunology, personalized vaccines offer the promise of enhanced efficacy and safety, revolutionizing the field of vaccinology. However, the development of personalized vaccines presents multifaceted challenges, including technical, ethical, economic, and regulatory considerations. Addressing these challenges is essential to ensure equitable access and safety of personalized vaccination strategies. Despite these hurdles, the potential of personalized vaccines to optimize responses and mitigate disease burden underscores the significance of ongoing research and collaboration in advancing precision medicine in immunization.

引用

页数：11

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