Senescence as a molecular target in skin aging and disease

被引：0

作者：

Thau, Henriette ^{[1
,2
,3
,4
,5
]}

Gerjol, Bastian P. ^{[6
]}

Hahn, Katharina ^{[7
]}

von Gudenberg, Rosalie Wolff ^{[8
]}

Knoedler, Leonard ^{[4
,5
,9
,10
]}

Stallcup, Kenneth ^{[2
]}

Emmert, Maximilian Y. ^{[2
,3
,4
,5
,11
]}

Buhl, Timo ^{[7
]}

Wyles, Saranya P. ^{[12
]}

Tchkonia, Tamar ^{[13
]}

Tullius, Stefan G. ^{[8
]}

Iske, Jasper ^{[2
,3
,4
,5
]}

机构：

[1] Mayo Clin, Van Cleve Cardiac Regenerat Med Program, Rochester, MN USA

[2] Deutsches Herzzentrum Charite DHZC, Dept Cardiothorac & Vasc Surg, Berlin, Germany

[3] Charite Univ Med Berlin, Berlin, Germany

[4] Free Univ Berlin, Berlin, Germany

[5] Humboldt Univ, Berlin, Germany

[6] Klin Hirslanden, Dept Internal Med, Zurich, Switzerland

[7] Gottingen Univ Med Ctr, Dept Dermatol Venereol & Allergol, Gottingen, Germany

[8] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Transplant Surg, Boston, MA USA

[9] Charite Univ Med Berlin, Dept Oral & Maxillofacial Surg, Berlin, Germany

[10] Berlin Inst Hlth, Berlin, Germany

[11] Univ Zurich, Inst Regenerat Med IREM, Zurich, Switzerland

[12] Mayo Clin, Dept Dermatol, Rochester, MN USA

[13] Cedars Sinai Med Ctr, Ctr Adv Gerotherapeut, Los Angeles, CA USA

来源：

AGEING RESEARCH REVIEWS | 2025年 / 105卷

关键词：

Skin aging; Senescence; Senescent cell; senolytics; Anti-aging; P16INK4A POSITIVE CELLS; ORAL LICHEN-PLANUS; CELLULAR SENESCENCE; MATRIX METALLOPROTEINASES; OXIDATIVE STRESS; GENE-EXPRESSION; DNA-DAMAGE; TNF-ALPHA; EPIDERMAL-KERATINOCYTES; SECRETORY PHENOTYPE;

D O I：

10.1016/j.arr.2025.102686

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Skin aging represents a multifactorial process influenced by both intrinsic and extrinsic factors, collectively known as the skin exposome. Cellular senescence, characterized by stable cell cycle arrest and secretion of proinflammatory molecules, has been implicated as a key driver of physiological and pathological skin aging. Increasing evidence points towards the role of senescence in a variety of dermatological diseases, where the accumulation of senescent cells in the epidermis and dermis exacerbates disease progression. Emerging therapeutic strategies such as senolytics and senomorphics offer promising avenues to target senescent cells and mitigate their deleterious effects, providing potential treatments for both skin aging and senescence-associated skin diseases. This review explores the molecular mechanisms of cellular senescence and its role in promoting age-related skin changes and pathologies, while compiling the observed effects of senotherapeutics in the skin and discussing the translational relevance.

引用

页数：16

共 255 条

[1] The STATus of STAT3 in Lung Cell Senescence? [J].

Adnot, Serge ;

Lipskaia, Larissa ;

Bernard, David .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2019, 61 (01) :5-6

[2]

Albanesi C., 2005, Ski. Dis., P329

[3] A Systematic Review Evaluating the Effectiveness of Several Biological Therapies for the Treatment of Skin Psoriasis [J].

Alzahrani, Sattam A. ;

Alzamil, Fajer M. ;

Aljuhni, Abdulaziz M. ;

Thaqfan, Naif A. Al ;

Alqahtani, Norah Y. ;

Alwarwari, Sara A. ;

Alkharashi, Abdullah A. ;

Alzabadin, Rakan A. ;

Alzehairi, Reema A. ;

Alhajlah, Abdullah A. .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (12)

[4]

Alzforum, 2023, Therapeutics: Dasatinib + Quercetin

[5] Role of Senescent Cells in Cutaneous Wound Healing [J].

Andrade, Allison M. M. ;

Sun, Mingda ;

Gasek, Nathan S. S. ;

Hargis, Geneva R. R. ;

Sharafieh, Roshanak ;

Xu, Ming .

BIOLOGY-BASEL, 2022, 11 (12)

[6] Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin [J].

Bacqueville, Daniel ;

Maret, Anne ;

Noizet, Maite ;

Duprat, Laure ;

Coutanceau, Christine ;

Georgescu, Victor ;

Bessou-Touya, Sandrine ;

Duplan, Helene .

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2020, 13 :359-370

[7] TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis [J].

Bae, Eun-Jin ;

Choi, Minsun ;

Kim, Jeong Tae ;

Kim, Dong-Kyu ;

Jung, Min Kyo ;

Kim, Changyoun ;

Kim, Tae-Kyung ;

Lee, Jun Sung ;

Jung, Byung Chul ;

Shin, Soo Jean ;

Rhee, Ka Hyun ;

Lee, Seung-Jae .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, 54 (06) :788-800

[8] Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes [J].

Baek, Hyoung-Seok ;

Kwon, Tae-Uk ;

Shin, Sangyun ;

Kwon, Yeo-Jung ;

Chun, Young-Jin .

SCIENTIFIC REPORTS, 2021, 11 (01)

[9] Epidermolysis bullosa [J].

Bardhan, Ajoy ;

Bruckner-Tuderman, Leena ;

Chapple, Iain L. C. ;

Fine, Jo-David ;

Harper, Natasha ;

Has, Cristina ;

Magin, Thomas M. ;

Marinkovich, M. Peter ;

Marshall, John F. ;

McGrath, John A. ;

Mellerio, Jemima E. ;

Polson, Rex ;

Heagerty, Adrian H. .

NATURE REVIEWS DISEASE PRIMERS, 2020, 6 (01)

[10] KERATINOCYTES AS INITIATORS OF INFLAMMATION [J].

BARKER, JNWN ;

MITRA, RS ;

GRIFFITHS, CEM ;

DIXIT, VM ;

NICKOLOFF, BJ .

LANCET, 1991, 337 (8735) :211-214

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