Cognitive Impairments Related to COMT and Neuregulin 1 Phenotypes as Transdiagnostic Markers in Schizophrenia Spectrum Patients

被引:0
作者
Bondrescu, Mariana [1 ,2 ,3 ]
Dehelean, Liana [1 ,2 ]
Farcas, Simona Sorina [4 ]
Papava, Ion [1 ,2 ]
Nicoras, Vlad [2 ]
Podaru, Carla Andreea
Sava, Madalina [2 ]
Bilavu, Elena Sabina [2 ]
Putnoky, Sandra [2 ]
Andreescu, Nicoleta Ioana [4 ]
机构
[1] Victor Babes Univ Med & Pharm, Dept Neurosci Psychiat, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[2] Timis Cty Emergency Clin Hosp Pius Brinzeu, Liviu Rebreanu 156, Timisoara 300723, Romania
[3] Victor Babes Univ Med & Pharm, Doctoral Sch, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[4] Victor Babes Univ Med & Pharm, Ctr Genom Med, Discipline Med Genet, Dept Microscop Morphol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
关键词
cognitive impairments; neuregulin; 1; COMT; schizophrenia spectrum disorders; GENE POLYMORPHISMS; NEUROPSYCHOLOGICAL PERFORMANCE; ADULT SCHIZOPHRENIA; EPISODIC MEMORY; ASSOCIATION; RISK; PSYCHOSIS; DISORDER; NEUROCOGNITION; RELIABILITY;
D O I
10.3390/jcm13216405
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Research on the interaction between antipsychotic treatment and cognitive dysfunction in schizophrenia spectrum disorders (SSDs) is extensive, yet the role of genetic polymorphisms in catechol-O-methyltransferase (COMT) and neuregulin 1 (NRG1) remains underexplored. Methods: This study evaluates the impact of COMT (rs4680) and NRG1 (rs3924999 and rs35753505) polymorphisms on cognitive functions in SSD patients. A cross-sectional study was conducted with fifty-four patients, assessed using the Positive and Negative Syndrome Scale (PANSS) and the CNS Vital Signs battery. Results: Significant cognitive function differences were observed across SSD diagnostic categories (p < 0.001). The NRG1 rs35753505 TT genotype was significantly associated with better verbal memory performance compared to the CC genotype (p = 0.03), while no significant differences were observed for other genotypes. The NRG1 rs3924999 AA genotype showed superior reasoning performance compared to AG and GG genotypes (p = 0.01), with AG and GG associated with lower scores (p = 0.01 and p = 0.02, respectively). Additionally, the COMT Val158Met genotype significantly influenced processing speed, with patients at the first episode of psychosis showing higher scores than chronic patients (p = 0.01). Conclusions: These findings suggest that NRG1 and COMT polymorphisms may influence cognitive domains in schizophrenia spectrum disorders, potentially informing personalized treatment and cognitive rehabilitation strategies.
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页数:19
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