Real-world Effectiveness and Tolerability of Interferon-free Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C: A Multinational Cohort Study

被引：0

作者：

Ji, Fanpu ^{[1
]}

Tran, Sally ^{[2
]}

Ogawa, Eiichi ^{[3
]}

Huang, Chung-Feng ^{[4
,5
,6
]}

Suzuki, Takanori ^{[7
]}

Wong, Yu Jun ^{[8
,9
]}

Toyoda, Hidenori ^{[10
]}

Jun, Dae Won ^{[11
,12
]}

Li, Liu ^{[13
]}

Uojima, Haruki ^{[14
]}

Nozaki, Akito ^{[15
]}

Chuma, Makoto ^{[15
]}

Tseng, Cheng-Hao ^{[16
]}

Hsu, Yao-Chun ^{[16
]}

Ishigami, Masatoshi ^{[17
]}

Honda, Takashi ^{[17
]}

Atsukawa, Masanori ^{[18
]}

Haga, Hiroaki ^{[19
]}

Enomoto, Masaru ^{[20
,21
]}

Trinh, Huy ^{[22
]}

Preda, Carmen Monica ^{[23
]}

Vutien, Phillip ^{[24
]}

Landis, Charles ^{[24
]}

Lee, Dong Hyun ^{[25
]}

Watanabe, Tsunamasa ^{[26
]}

Takahashi, Hirokazu ^{[27
,28
]}

Abe, Hiroshi ^{[29
]}

Asai, Akira ^{[30
]}

Eguchi, Yuichiro ^{[27
,31
]}

Li, Jie ^{[32
]}

Wang, Xiaozhong ^{[33
]}

Li, Jia ^{[34
]}

Liu, Junping ^{[35
]}

Liang, Jing ^{[36
]}

Lam, Carla Pui-Mei ^{[37
]}

Huang, Rui ^{[32
]}

Ye, Qing ^{[36
]}

Pan, Hongying ^{[38
]}

Zhang, Jiajie ^{[38
]}

Cai, Dachuan ^{[39
]}

Wang, Qi ^{[40
]}

Huang, Daniel Q. ^{[41
,42
]}

Wong, Grace ^{[43
,44
]}

Wong, Vincent Wai-Sun ^{[43
]}

Li, Junyi ^{[13
]}

Do, Son ^{[45
]}

Furusyo, Norihiro ^{[46
]}

Nakamuta, Makoto ^{[47
]}

Nomura, Hideyuki ^{[48
]}

Kajiwara, Eiji ^{[49
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Infect Dis, Xian, Shaanxi, Peoples R China

[2] Stanford Univ, Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Palo Alto, CA USA

[3] Kyushu Univ Hosp, Dept Gen Internal Med, Fukuoka, Japan

[4] Kaohsiung Med Univ Hosp, Dept Internal Med, Hepatobiliary Div, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Coll Med, Hepatitis Res Ctr, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Ctr Liquid Biopsy & Cohort Res, Kaohsiung, Taiwan

[7] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Nagoya, Aichi, Japan

[8] Singhlth, Changi Gen Hosp, Gastroenterol & Hepatol, Singapore, Singapore

[9] Singhlth Duke NUS Med, Acad Clin Program, Singapore, Singapore

[10] Ogaki Municipal Hosp, Dept Gastroenterol, Ogaki, Japan

[11] Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[12] Hanyang Univ, Hanyang Inst Biosci & Biotechnol, Seoul, South Korea

[13] Third Peoples Hosp Kunming City, Dept Hepatol, Kunming, Yunnan, Peoples R China

[14] Kitasato Univ, Sch Med, Dept Gastroenterol Internal Med, Sagamihara, Kanagawa, Japan

[15] Yokohama City Univ, Med Ctr, Gastroenterol Ctr, Yokohama, Kanagawa, Japan

[16] E Da Canc Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Kaohsiung, Taiwan

[17] Nagoya Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Nagoya, Aichi, Japan

[18] Nippon Med Sch, Div Gastroenterol & Hepatol, Tokyo, Japan

[19] Yamagata Univ, Fac Med, Dept Gastroenterol, Yamagata, Japan

[20] Osaka Metropolitan Univ, Dept Transfus Med, Osaka, Japan

[21] Osaka Metropolitan Univ, Grad Sch Med, Dept Hepatol, Osaka, Japan

[22] San Jose Gastroenterol, San Jose, CA USA

[23] Clin Fundeni Inst, Gastroenterol & Hepatol Dept, Bucharest, Romania

[24] Univ Washington, Div Gastroenterol & Hepatol, Seattle, WA USA

[25] Good Gang An Hosp, Dept Gastroenterol, Busan, South Korea

[26] St Marianna Univ, Sch Med, Div Gastroenterol & Hepatol, Kawasaki, Kanagawa, Japan

[27] Saga Univ Hosp, Liver Ctr, Saga, Japan

[28] Saga Univ, Fac Med, Div Metab & Endocrinol, Saga, Japan

[29] Shinmatsudo Cent Gen Hosp, Div Gastroenterol & Hepatol, Chiba, Japan

[30] Osaka Med & Pharmaceut Univ, Dept Internal Med 2, Osaka, Japan

[31] Locomed Eguchi Hosp, Locomed Gen Inst, Saga, Japan

[32] Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Dept Infect Dis,Med Sch, Nanjing, Jiangsu, Peoples R China

[33] Xinjiang Med Univ, Affiliated Tradit Chinese Med Hosp, Urumqi, Xinjiang, Peoples R China

[34] Second Peoples Hosp Tianjin, Dept Gastroenterol & Hepatol, Tianjin, Peoples R China

[35] Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Infect Dis, Zhengzhou, Henan, Peoples R China

[36] Third Cent Hosp Tianjin, Dept Gastroenterol & Hepatol, Tianjin, Peoples R China

[37] Univ Hong Kong, Dept Med, Hong Kong, Peoples R China

[38] Zhejiang Univ, Zhejiang Prov Peoples Hosp, Dept Hepatol, Hangzhou, Zhejiang, Peoples R China

[39] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Chongqing, Peoples R China

[40] Capital Med Univ, Beijing Ditan Hosp, Ctr Liver Dis, Beijing, Peoples R China

[41] Natl Univ Singapore Hosp, Div Gastroenterol & Hepatol, Singapore, Singapore

[42] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore

[43] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China

[44] Chinese Univ Hong Kong, State Key Lab Digest Dis, Hong Kong, Peoples R China

[45] Digest Hlth Associates Texas, Dallas, TX USA

[46] Taihaku Ave Clin, Fukuoka, Japan

[47] Natl Hosp Org, Kyushu Med Ctr, Dept Gastroenterol, Fukuoka, Japan

[48] Haradoi Hosp, Dept Internal Med, Fukuoka, Japan

[49] Kajiwara Clin, Hepatol Clin, Kitakyushu, Fukuoka, Japan

[50] Eulji Univ, Coll Med, Nowon Eulji Med Ctr, Dept Internal Med, Seoul, South Korea

来源：

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2024年 / 12卷 / 07期

关键词：

Hepatitis C virus; Liver cirrhosis; Hepatocellular carcinoma; Genotype; DAA; REAL-C; VELPATASVIR; SOFOSBUVIR; INFECTION; THERAPY; HCV;

D O I：

10.14218/JCTH.2024.00089

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aims: As practice patterns and hepatitis C virus (HCV) genotypes (GT) vary geographically, a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination goal. This study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs, focusing on GT3 and GT6. Methods: We analyzed the sustained virological response (SVR12) of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific, North America, and Europe between 07/01/2014-07/01/2021. Results: The mean age was 62 +/- 13 years, with 49.6% male. The demographic breakdown was 91.1% Asian (52.9% Japanese, 25.7% Chinese/Taiwanese, 5.4% Korean, 3.3% Malaysian, and 2.9% Vietnamese), 6.4% White, 1.3% Hispanic/Latino, and 1% Black/African-American. Additionally, 34.8% had cirrhosis, 8.6% had hepatocellular carcinoma (HCC), and 24.9% were treatment-experienced (20.7% with interferon, 4.3% with direct-acting antivirals). The largest group was GT1 (10,246 [64.6%]), followed by GT2 (3,686 [23.2%]), GT3 (1,151 [7.2%]), GT6 (457 [2.8%]), GT4 (47 [0.3%]), GT5 (1 [0.006%]), and untyped GTs (261 [1.6%]). The overall SVR12 was 96.9%, with rates over 95% for GT1/2/3/6 but 91.5% for GT4. SVR12 for GT3 was 95.1% overall, 98.2% for GT3a, and 94.0% for GT3b. SVR12 was 98.3% overall for GT6, lower for patients with cirrhosis and treatment-experienced (TE) (93.8%) but >= 97.5% for treatment-naive patients regardless of cirrhosis status. On multivariable analysis, advanced age, prior treatment failure, cirrhosis, active HCC, and GT3/4 were independent predictors of lower SVR12, while being Asian was a significant predictor of achieving SVR12. Conclusions: In this diverse multinational real-world cohort of patients with various GTs, the overall cure rate was 96.9%, despite large numbers of patients with cirrhosis, HCC, TE, and GT3/6. SVR12 for GT3/6 with cirrhosis and TE was lower but still excellent (>91%).

引用

页码：646 / 658

页数：13

共 32 条

[1] Hepatitis C Guidance 2023 Update: American Association for the Study of Liver Diseases- Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection
Bhattacharya, Debika
Aronsohn, Andrew
Price, Jennifer
Lo Re, Vincent, III
[J]. CLINICAL INFECTIOUS DISEASES, 2023,
[2] Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study
Blach, Sarah
Terrault, Norah A.
Tacke, Frank
Gamkrelidze, Ivane
Craxi, Antonio
Tanaka, Junko
Waked, Imam
Dore, Gregory J.
Abbas, Zaigham
Abdallah, Ayat R.
Abdulla, Maheeba
Aghemo, Alessio
Aho, Inka
Akarca, Ulus S.
Alalwan, Abduljaleel M.
Blome, Marianne Alanko
Al-Busafi, Said A.
Aleman, Soo
Alghamdi, Abdullah S.
Al-Hamoudi, Waleed K.
Aljumah, Abdulrahman A.
Al-Naamani, Khalid
Al Serkal, Yousif M.
Altraif, Ibrahim H.
Anand, Anil C.
Anderson, Motswedi
Andersson, Monique, I
Athanasakis, Kostas
Baatarkhuu, Oidov
Bakieva, Shokhista R.
Ben-Ari, Ziv
Bessone, Fernando
Biondi, Mia J.
Bizri, Abdul Rahman N.
Mello, Carlos E. Brandaoo
Brigida, Krestina
Brown, Kimberly A.
Brown, Robert S., Jr.
Bruggmann, Philip
Brunetto, Maurizia R.
Busschots, Dana
Buti, Maria
Butsashvili, Maia
Cabezas, Joaquin
Chae, Chungman
Ivanova, Viktorija Chaloska
Chan, Henry Lik Yuen
Cheinquer, Hugo
Cheng, Kent Jason
Cheon, Myeong Eun
[J]. LANCET GASTROENTEROLOGY & HEPATOLOGY, 2022, 7 (05): : 396 - 415
[3] Hepatitis C genotype 6: A concise review and response-guided therapy proposal
Bunchorntavakul, Chalermrat
Chavalitdhamrong, Disaya
Tanwandee, Tawesak
[J]. WORLD JOURNAL OF HEPATOLOGY, 2013, 5 (09) : 496 - 504
[4] Hepatic benefits of HCV cure
Calvaruso, Vincenza
Craxi, Antonio
[J]. JOURNAL OF HEPATOLOGY, 2020, 73 (06) : 1548 - 1556
[5] Real-world effectiveness and safety of sofosbuvir and nonstructural protein 5A inhibitors for chronic hepatitis C genotype 1, 2, 3, 4, or 6: a multicentre cohort study
Charatcharoenwitthaya, Phunchai
Wongpaitoon, Virasak
Komolmit, Piyawat
Sukeepaisarnjaroen, Wattana
Tangkijvanich, Pisit
Piratvisuth, Teerha
Sanpajit, Theeranun
Sutthivana, Chinnavat
Bunchorntavakul, Chalermrat
Sobhonslidsuk, Abhasnee
Chonprasertsuk, Soonthorn
Siripipattanamongkol, Chotipong
Sethasine, Supatsri
Tanwandee, Tawesak
[J]. BMC GASTROENTEROLOGY, 2020, 20 (01)
[6] Factors associated with treatment failure of direct-acting antivirals for chronic hepatitis C: A real-world nationwide hepatitis C virus registry programme in Taiwan
Chen, Chi-Yi
Huang, Chung-Feng
Cheng, Pin-Nan
Tseng, Kuo-Chih
Lo, Ching-Chu
Kuo, Hsing-Tao
Huang, Yi-Hsiang
Tai, Chi-Ming
Peng, Cheng-Yuan
Bair, Ming-Jong
Chen, Chien-Hung
Yeh, Ming-Lun
Lin, Chih-Lang
Lin, Chun-Yen
Lee, Pei-Lun
Chong, Lee-Won
Hung, Chao-Hung
Huang, Jee-Fu
Yang, Chi-Chieh
Hu, Jui-Ting
Lin, Chih-Wen
Chen, Chun-Ting
Wang, Chia-Chi
Su, Wei-Wen
Hsieh, Tsai-Yuan
Lin, Chih-Lin
Tsai, Wei-Lun
Lee, Tzong-Hsi
Chen, Guei-Ying
Wang, Szu-Jen
Chang, Chun-Chao
Mo, Lein-Ray
Yang, Sheng-Shun
Wu, Wen-Chih
Huang, Chia-Sheng
Hsiung, Chou-Kwok
Kao, Chien-Neng
Tsai, Pei-Chien
Liu, Chen-Hua
Lee, Mei-Hsuan
Liu, Chun-Jen
Dai, Chia-Yen
Kao, Jia-Horng
Chuang, Wan-Long
Lin, Han-Chieh
Yu, Ming-Lung
[J]. LIVER INTERNATIONAL, 2021, 41 (06) : 1265 - 1277
[7] Hepatitis C virus genotypes and subtypes circulating in Mainland China
Chen, Ying
Yu, Changshun
Yin, Xueru
Guo, Xiaolei
Wu, Shangwei
Hou, Jinlin
[J]. EMERGING MICROBES & INFECTIONS, 2017, 6
[8] Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis
Curry, M. P.
O'Leary, J. G.
Bzowej, N.
Muir, A. J.
Korenblat, K. M.
Fenkel, J. M.
Reddy, K. R.
Lawitz, E.
Flamm, S. L.
Schiano, T.
Teperman, L.
Fontana, R.
Schiff, E.
Fried, M.
Doehle, B.
An, D.
McNally, J.
Osinusi, A.
Brainard, D. M.
McHutchison, J. G.
Brown, R. S., Jr.
Charlton, M.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (27) : 2618 - 2628
[9] Cure With Interferon-Free Direct-Acting Antiviral Is Associated With Increased Survival in Patients With Hepatitis C Virus-Related Hepatocellular Carcinoma From Both East and West
Dang, Hansen
Yeo, Yee Hui
Yasuda, Satoshi
Huang, Chung-Feng
Iio, Etsuko
Landis, Charles
Jun, Dae Won
Enomoto, Masaru
Ogawa, Eiichi
Tsai, Pei-Chien
Le, An
Liu, Matthew
Maeda, Mayumi
Nguyen, Brian
Ramrakhiani, Nathan
Henry, Linda
Cheung, Ramsey
Tamori, Akihiro
Kumada, Takashi
Tanaka, Yasuhito
Yu, Ming-Lung
Toyoda, Hidenori
Nguyen, Mindie H.
[J]. HEPATOLOGY, 2020, 71 (06) : 1910 - 1922
[10] Efficacy of Sofosbuvir and Velpatasvir, With and Without Ribavirin, in Patients With Hepatitis C Virus Genotype 3 Infection and Cirrhosis
Esteban, Rafael
Pineda, Juan A.
Luis Calleja, Jose
Casado, Marta
Rodriguez, Manuel
Turnes, Juan
Morano Amado, Luis Enrique
Maria Morillas, Rosa
Forns, Xavier
Pascasio Acevedo, Juan Manuel
Andrade, Raul J.
Rivero, Antonio
Antonio Carrion, Jose
Lens, Sabela
Riveiro-Barciela, Mar
McNabb, Brian
Zhang, Gulan
Camus, Gregory
Stamm, Luisa M.
Brainard, Diana M.
Subramanian, G. Mani
Buti, Maria
[J]. GASTROENTEROLOGY, 2018, 155 (04) : 1120 - +

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