Total synthesis of breviscapin B via intramolecular dehydrative etherification

被引：0
|
作者：
Makino, Kosho [1 ,2 ]
Nogami, Chiharu [1 ]
Sueki, Shunsuke [1 ,2 ]
Anada, Masahiro [1 ,2 ]
机构：
[1] Musashino Univ, Fac Pharm, 1-1-20, Shinmachi, Nishitokyo, Tokyo 2028585, Japan
[2] Musashino Univ, Res Inst Pharmaceut Sci, 1-1-20, Shinmachi, Nishitokyo, Tokyo 2028585, Japan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年
基金：
日本学术振兴会;
关键词：
POLYCYCLIC SPIRO LIGNANS; UNSYMMETRICAL ETHERS; ALCOHOLS; DERIVATIVES;
D O I：
10.1039/d5ob00350d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of breviscapin B, a norlignan natural product having an unusual 2,2-diaryltetrahydrofuran skeleton, has been achieved via intramolecular dehydrative Williamson ether synthesis as a key step. The use of a combination of p-TsOH<middle dot>H2O and polyfluorinated alcohol was found as an effective method for the synthesis of 2-aryl-substituted saturated oxygen heterocycles.
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页数：6
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