HBr/TMSO/HFIP Mediated Chemoselective Modifications of Pyrrolo[2,1-a]Isoquinolines

被引：1
|
作者：
Li, Yun-Meng [1 ]
Jiang, Man [1 ]
Zhou, Jing [1 ]
Cui, Hai-Lei [1 ]
机构：
[1] Chongqing Univ Arts & Sci, Coll Chem & Environm Engn, Lab Asymmetr Synth, 319 Honghe Ave, Chongqing 402160, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Bromination; Dimerization; Pyrrolo[2,1-a]isoquinoline; Sulfenylation; Tetramethylene sulfoxide; DIMETHYL-SULFOXIDE; CONVENIENT ACCESS; N-METHYLATION; DMSO; BROMINATION; OXIDATION; EFFICIENT; ACID; OLEFINS; KETONES;
D O I：
10.1002/ajoc.202400323
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The combination of HBr, TMSO (tetramethylene sulfoxide) and HFIP (hexafluoroisopropanol) has been utilized in the modification of pyrrolo[2,1-a]isoquinoline derivatives through bromination, dimerization and sulfenylation respectively. In these processes, HBr serves as the source of bromine and TMSO acts as an oxidant. HFIP also plays an essential role for the oxidative dimerization. Chemoselectivity can be easily controlled by adjusting the parameters such as reaction time, ratio of reagents and the addition of nucleophile.
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页数：9
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