Anti-inflammatory Activity of 1-Substituted Glyoxal β- Carboline Derivatives

被引:0
作者
Zulkifli, Siti Zafirah [1 ,2 ]
Asha'ari, Nur Ain Nabilah [1 ,2 ]
Aziz, Ahmad Fawwaz Aiman [1 ]
Pungot, Noor Hidayah [1 ,2 ]
机构
[1] Univ Teknol MARA UiTM, Shah Alam Campus, Shah Alam 40450, Selangor, Malaysia
[2] Univ Teknol MARA, Inst Sci IOS, Organ Synth Lab, Puncak Alam Campus, Bandar Puncak Alam 43200, Selangor, Malaysia
来源
MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES | 2024年 / 20卷 / 05期
关键词
1-Substituted R-carboline; Activated glyoxal; L-; Tryptophan; Anti-inflammatory; Xanthine oxidase (XO); XANTHINE-OXIDASE; ALKALOIDS;
D O I
10.11113/mjfas.v20n5.3630
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The anti-inflammatory properties of R-carbolines have been widely studied, highlighting their potential in treating inflammatory disorders. This research investigates the antiinflammatory activity of selected 1-substituted glyoxal R-carboline derivatives, achieved through a one-step conversion of 5-hydroxy-L-tryptophan with activated glyoxal, without forming tetrahydroR-carboline (THRC) intermediates. These derivatives (4e 4e-g ) were synthesized successfully without requiring expensive metal catalysts, prolonged reaction times, or stringent reaction conditions, and yielded moderate amounts. Our findings indicate that all the derivatives significantly inhibit xanthine oxidase (XO) activity, leading to a reduction in reactive oxygen species (ROS) and free radicals. This inhibition disrupts the inflammatory cascade and attenuates the inflammatory response.
引用
收藏
页码:1228 / 1234
页数:7
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