A Solvent-Free 2-Chloro-1-methylpyridinium Iodide (CMPI)-Mediated Biginelli Reaction for the Construction of 3,4-Dihydropyrimidin-2(1 H )-ones/thiones

被引：0

作者：

Kumar, Ashish ^{[1
,2
]}

Pandey, Shashi ^{[3
]}

Gupta, Monika ^{[1
]}

Rajput, Chatrasal S. ^{[2
]}

机构：

[1] Babu Banarasi Das Univ, Sch Basic Sci, Dept Chem, Lucknow 226028, Uttar Pradesh, India

[2] Jubilant Biosys Ltd, Chem Innovat Res Ctr, Greater Noida 201310, Uttar Pradesh, India

[3] Univ Lucknow, Fac Sci, Dept Chem, Lucknow 226007, Uttar Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2025年 / 57卷 / 07期

关键词：

Biginelli reaction; CMPI; 3,4-dihydropyrimidin-2(1 H )-ones/thiones (DHPMs); one-pot condensation; tri-component reaction; ONE-POT SYNTHESIS; PYRIMIDINE-DERIVATIVES; IONIC LIQUIDS; CATALYST; ACID; EFFICIENT; DIHYDROPYRIMIDINONES; PROTOCOL; REAGENT; DESIGN;

D O I：

10.1055/a-2508-9681

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Biginelli product dihydropyrimidinones (DHPMs) and their derivatives have enormous biological significance. This article describes the exploration of 2-chloro-1-methylpyridinium iodide (CMPI) reagent for the development of an environmentally safe, solvent-free protocol to construct the functionalized 3,4-dihydropyrimidin-2(1H)- ones/thiones. The protocol involves the three-component condensation reaction of beta-keto ester, aldehyde, and urea or thiourea at elevated temperature. The key advantages of the protocol are its capacity to provide both environmental and economic benefits owing to its solvent-free conditions, short reaction times, simple workup, and good to excellent isolated yield of DHPMs.

引用

页码：1329 / 1338

页数：10

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