Synthesis, Diagnosis As Well as Biological Activity Studies of Some Metal Ion Complexes of Schiff Bases Derived from 4-Aminoantipyrine

Polydintate Schiff base ligands L1 = orthohydroxy aniline, 4-aminoantipyrin-(N,N<overline> benzilidene) and L2 = 5-Chloro2-hydroxyaniline,4-aminoantipyrine-(N,N<overline>) benzilide obtained from condensation of benzil and 4-aminoantipyrine with 2-aminophenol or 2-amino 4-chlorophenol in (1:1:1) molar ratio for each component. Ligands employed to synthesis complexes in the general molecular formula [ML1Cl]Cl and [ML2]Cl2 respectively; M = Mn(II), Co(II), Ni(II) and Zn(II). To diagnose the ligands and the complexes the following techniques were adopted: UV-Visible FTIR and 1H-NMR spectroscopies, micro elemental analyses of metal ions and carbon, hydrogen and nitrogen, molar conductivity magnetic susceptibility. Measurements obtained from the conductivity which was done with DMSO solution indicated that all the complexes are electrolytes with ratio (1:1) for L1 complexes and (1:2) for L2 complexes. The results of measurements which used in this study showed coordination sites for L1 with central ion were through the phenolic oxygen atom, and two nitrogen atoms of the azomethin groups, L2 in addition to the previous donor atoms, coordination is carried out by the oxygen atom of the terminal carbonyl group. All complexes are tetra-coordinate with (tetrahedral geometry). Evaluation of biological activity for the compounds tested against Gram (+) staphylococcus aurous and Gram (-) Klebsiella pneumonia.