Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study

被引:3
|
作者
Swank, Zoe [1 ,2 ,3 ]
Borberg, Ella [1 ,2 ,3 ]
Chen, Yulu [3 ,4 ]
Senussi, Yasmeen [1 ,2 ,3 ]
Chalise, Sujata [1 ,2 ,3 ]
Manickas-Hill, Zachary [5 ]
Yu, Xu G. [3 ,5 ,6 ]
Li, Jonathan Z. [3 ,6 ]
Alter, Galit [5 ,7 ]
Henrich, Timothy J. [8 ]
Kelly, J. Daniel [9 ,10 ,11 ]
Hoh, Rebecca [12 ]
Goldberg, Sarah A. [9 ]
Deeks, Steven G. [12 ]
Martin, Jeffrey N. [9 ]
Peluso, Michael J. [12 ]
Talla, Aarthi [13 ]
Li, Xiaojun [13 ]
Skene, Peter [13 ]
Bumol, Thomas F. [13 ]
Torgerson, Troy R. [13 ]
Czartoski, Julie L. [14 ]
Mcelrath, M. Juliana [14 ]
Karlson, Elizabeth W. [3 ,15 ]
Walt, David R. [1 ,2 ,3 ]
机构
[1] Brigham & Womens Hosp, Dept Pathol, 60 Fenwood Rd, Boston, MA 02115 USA
[2] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02138 USA
[3] Harvard Med Sch, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA
[5] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA
[6] Brigham & Womens Hosp, Div Infect Dis, Boston, MA USA
[7] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA USA
[8] Univ Calif San Francisco, Div Expt Med, San Francisco, CA USA
[9] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA
[10] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[11] San Francisco VA Med Ctr, San Francisco, CA USA
[12] Univ Calif San Francisco, Div HIV Infect Dis & Global Med, San Francisco, CA USA
[13] Allen Inst Immunol, Seattle, WA USA
[14] Fred Hutchinson Canc Ctr, Seattle, WA USA
[15] Brigham & Womens Hosp, Dept Med, Boston, MA USA
基金
美国国家卫生研究院;
关键词
COVID-19; Multicohort study; Postacute sequelae of COVID-19; Retrospective cohort study; SARS-CoV-2; antigens; PERSISTENCE; COVID-19;
D O I
10.1016/j.cmi.2024.09.001
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: To determine the proportion of individuals with detectable antigen in plasma or serum after SARS-CoV-2 infection and the association of antigen detection with postacute sequelae of COVID-19 (PASC) symptoms. Methods: Plasma and serum samples were collected from adults participating in four independent studies at different time points, ranging from several days up to 14 months post-SARS-CoV-2 infection. The primary outcome measure was to quantify SARS-CoV-2 antigens, including the S1 subunit of spike, full-length spike, and nucleocapsid, in participant samples. The presence of 34 commonly reported PASC symptoms during the postacute period was determined from participant surveys or chart reviews of electronic health records. Results: Of the 1569 samples analysed from 706 individuals infected with SARS-CoV-2, 21% (95% CI, 18-24%) were positive for either S1, spike, or nucleocapsid. Spike was predominantly detected, and the highest proportion of samples was spike positive (20%; 95% CI, 18-22%) between 4 and 7 months postinfection. In total, 578 participants (82%) reported at least one of the 34 PASC symptoms included in our analysis >1 month postinfection. Cardiopulmonary, musculoskeletal, and neurologic symptoms had the highest reported prevalence in over half of all participants, and among those participants, 43% (95% CI, 40-45%) on average were antigen-positive. Among the participants who reported no ongoing symptoms (128, 18%), antigen was detected in 28 participants (21%). The presence of antigen was associated with the presence of one or more PASC symptoms, adjusting for sex, age, time postinfection, and cohort (OR, 1.8; 95% CI, 1.4-2.2). Discussion: The findings of this multicohort study indicate that SARS-CoV-2 antigens can be detected in the blood of a substantial proportion of individuals up to 14 months after infection. While approximately one in five asymptomatic individuals was antigen-positive, roughly half of all individuals reporting ongoing cardiopulmonary, musculoskeletal, and neurologic symptoms were antigen-positive. Zoe Swank, Clin Microbiol Infect 2024;30:1599 (c) 2024 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
引用
收藏
页码:1599 / 1605
页数:7
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